Charlotte K Knatten1, Morten Kvello2, Thomas J Fyhn2, Bjørn Edwin3, Ole Schistad4, Lars Aabakken5, Are H Pripp6, Heidi Kjosbakken7, Ragnhild Emblem2, Kristin Bjørnland2. 1. Institute of Clinical Medicine, University of Oslo, Norway; Department of Gastrointestinal and Pediatric surgery, Oslo University Hospital, Rikshospitalet, Norway. Electronic address: charlotte@knatten.org. 2. Institute of Clinical Medicine, University of Oslo, Norway; Department of Gastrointestinal and Pediatric surgery, Oslo University Hospital, Rikshospitalet, Norway. 3. Institute of Clinical Medicine, University of Oslo, Norway; Intervention Centre, Oslo University Hospital, Rikshospitalet, Norway. 4. Department of Gastrointestinal and Pediatric surgery, Oslo University Hospital, Ullevål, Norway. 5. Institute of Clinical Medicine, University of Oslo, Norway; Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, Norway. 6. Oslo Centre of Biostatistics and Epidemiology, Oslo University Hospital, Norway. 7. Department of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, Norway.
Abstract
BACKGROUND: It is assumed that children with neurological impairment (NI) have inferior results after fundoplication compared to those without NI (non-NI). The aim of this study was to assess outcome after fundoplication in children with and without NI. METHODS:87/105 patients (46 NI, 41 non-NI) undergoing fundoplication between 2003 and 2009 were included in this prospective two-center cohort study. Complications occurring within the first 30days were scored from 0 to 100 by the comprehensive complication index (CCI). Follow-up included clinical examination, upper gastrointestinal contrast study and 24-h pH monitoring 6months postoperatively, then phone-interviews 1, 2 and 4years later. RESULTS: There were no statistical differences in age (NI 3.1 years [0.2-15.2] vs non-NI 5.0 years [0.4-15], p=.14) or in total CCI score (NI 20.9 [0-44.9] vs non-NI 8.7 [0-40.6], p=.57). Hospital stay was longer for NI children (9days [4-57] vs non-NI: 4days [2-16], p<0.001). More than 90% of parents in both groups reported that the fundoplication had improved the child's overall condition. Recurrence of gastroesophageal reflux disease (GERD) was diagnosed in 12 NI and 7 non-NI patients (p=.31). CONCLUSIONS:Early complications, GERD recurrence, and long-term parental satisfaction after fundoplication did not differ between NI and non-NI patients.
RCT Entities:
BACKGROUND: It is assumed that children with neurological impairment (NI) have inferior results after fundoplication compared to those without NI (non-NI). The aim of this study was to assess outcome after fundoplication in children with and without NI. METHODS: 87/105 patients (46 NI, 41 non-NI) undergoing fundoplication between 2003 and 2009 were included in this prospective two-center cohort study. Complications occurring within the first 30days were scored from 0 to 100 by the comprehensive complication index (CCI). Follow-up included clinical examination, upper gastrointestinal contrast study and 24-h pH monitoring 6months postoperatively, then phone-interviews 1, 2 and 4years later. RESULTS: There were no statistical differences in age (NI 3.1 years [0.2-15.2] vs non-NI 5.0 years [0.4-15], p=.14) or in total CCI score (NI 20.9 [0-44.9] vs non-NI 8.7 [0-40.6], p=.57). Hospital stay was longer for NI children (9days [4-57] vs non-NI: 4days [2-16], p<0.001). More than 90% of parents in both groups reported that the fundoplication had improved the child's overall condition. Recurrence of gastroesophageal reflux disease (GERD) was diagnosed in 12 NI and 7 non-NI patients (p=.31). CONCLUSIONS: Early complications, GERD recurrence, and long-term parental satisfaction after fundoplication did not differ between NI and non-NI patients.
Authors: Rebecca K Stellato; Nadia Colmer; Stefaan H A Tytgat; David C van der Zee; Femke A van de Peppel-Mauritz; Maud Y A Lindeboom Journal: J Gastrointest Surg Date: 2020-07-22 Impact factor: 3.452
Authors: Mohammed K AlNamshan; Nawaf M AlKharashi; Stanley J Crankson; Saud A AlJadaan; Nasir U Khawaja; Shahad A AlSaif Journal: Saudi Med J Date: 2019-08 Impact factor: 1.484
Authors: Anna Maria Caruso; Mario Milazzo; Vincenzo Tulone; Carlo Acierno; Vincenza Girgenti; Salvatore Amoroso; Denisia Bommarito; Valeria Calcaterra; Gloria Pelizzo Journal: Children (Basel) Date: 2020-11-07