Literature DB >> 26787106

Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.

Ana Moraga1, Vanessa Gómez-Vallejo2, María Isabel Cuartero1, Boguslaw Szczupak3, Eneko San Sebastián3, Irati Markuerkiaga3, Jesús M Pradillo1, Makoto Higuchi4, Jordi Llop2, María Ángeles Moro1, Abraham Martín5, Ignacio Lizasoain1.   

Abstract

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
© The Author(s) 2016.

Entities:  

Keywords:  3′-deoxy-3′-[18F]fluorothymidine; Positron emission tomography; T2W-MRI; [11C]PK11195; cerebral ischemia; magnetic resonance imaging; middle cerebral artery occlusion; toll-like receptor 4

Mesh：

Substances：

Year:  2016        PMID： 26787106      PMCID： PMC4821030          DOI： 10.1177/0271678X15627657

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  21 in total

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