| Literature DB >> 26786815 |
Harekrishna Sahoo1, Mallu Kesava Reddy1, Isai Ramakrishna1, Mahiuddin Baidya2.
Abstract
A copper-catalyzed 8-amide chelation-induced remote C-H amination of quinolines has been developed. This direct amination with readily available azodicarboxylates proceeded with perfect C5-regioselectivity offering amino-substituted 8-aminoquinolines, important bioactive molecular scaffolds, in very high yields (up to 96%). A single-electron transfer (SET)-mediated mechanism with kH /kD =1.1 was proposed after trapping of the radical intermediate.Entities:
Keywords: C−H activation; amination; azo compounds; copper; homogeneous catalysis
Year: 2016 PMID： 26786815 DOI： 10.1002/chem.201504207
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236