Literature DB >> 2678630

Functional evolutionary divergence of proteolytic enzymes and their inhibitors.

T E Creighton, N J Darby.   

Abstract

The amino acid residues of protease inhibitors that interact directly with proteases are hypervariable, suggesting recent positive evolutionary selection for functional differences between them. A similar hypervariability is apparent in some proteases, which may be co-evolving with the inhibitors.

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Substances：

Year:  1989        PMID： 2678630     DOI： 10.1016/0968-0004(89)90159-x

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  23 in total

1.  Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania.

Authors:  F Alvarez-Valin; J F Tort; G Bernardi
Journal:  Genetics       Date:  2000-08       Impact factor: 4.562

2.  Asymmetric mutation rates at enzyme-inhibitor interfaces: implications for the protein-protein docking problem.

Authors:  James R Bradford; David R Westhead
Journal:  Protein Sci       Date:  2003-09       Impact factor: 6.725

3.  Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking.

Authors:  Yasel Guerra; Pedro A Valiente; Colin Berry; Tirso Pons
Journal:  J Mol Model       Date:  2011-11-20       Impact factor: 1.810

4.  The squash aspartic proteinase inhibitor SQAPI is widely present in the cucurbitales, comprises a small multigene family, and is a member of the phytocystatin family.

Authors:  John T Christeller; Peter C Farley; Richelle K Marshall; Ananda Anandan; Michele M Wright; Richard D Newcomb; William A Laing
Journal:  J Mol Evol       Date:  2006-11-10       Impact factor: 2.395

5.  Amino acid sequences of ovomucoid third domain from 25 additional species of birds.

Authors:  M Laskowski; I Apostol; W Ardelt; J Cook; A Giletto; C A Kelly; W Y Lu; S J Park; M A Qasim; H E Whatley
Journal:  J Protein Chem       Date:  1990-12

Review 6.  Multigene families and the evolution of complexity.

Authors:  T Ohta
Journal:  J Mol Evol       Date:  1991-07       Impact factor: 2.395

7.  The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.

Authors:  J Deussing; W Roth; W Rommerskirch; B Wiederanders; K von Figura; C Peters
Journal:  Mamm Genome       Date:  1997-04       Impact factor: 2.957

8.  On hypervariability at the reactive center of proteolytic enzymes and their inhibitors.

Authors:  T Ohta
Journal:  J Mol Evol       Date:  1994-12       Impact factor: 2.395

9.  Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues.

Authors:  T L Bigler; W Lu; S J Park; M Tashiro; M Wieczorek; R Wynn; M Laskowski
Journal:  Protein Sci       Date:  1993-05       Impact factor: 6.725

10.  Nucleotide sequence of a mouse Tcp-1 pseudogene: a nucleotide record for a t complex gene carried by an ancestor of the mouse.

Authors:  H Kubota; T Morita; Y Satta; M Nozaki; A Matsushiro
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957
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