Constantine T Frantzides1, Shaun C Daly2, Alexander T Frantzides3, Thomas Manelis3, Algis Marcinkevicius3, Minh B Luu2. 1. Chicago Institute of Minimally Invasive Surgery, 4905 Old Orchard Center, Suite 409, Skokie, IL 60077, USA. Electronic address: shaun_daly@rush.edu. 2. Department of Surgery, Rush University Medical Center, Chicago, IL, USA. 3. Chicago Institute of Minimally Invasive Surgery, 4905 Old Orchard Center, Suite 409, Skokie, IL 60077, USA.
Abstract
BACKGROUND: We present long-term follow-up data on patients with esophageal high-grade dysplasia and/or carcinoma in situ who were treated with laparoscopic transgastric esophageal mucosal resection (LTEMR). METHODS: Patient demographics, operative outcomes, and follow-up results were tabulated. RESULTS: LTEMR was performed in 11 patients (9 male, 2 female). The median age was 54 (44 to 75) years. The 30-day morbidity or mortality was zero. The median follow-up was 5.2 (2 to 12) years. Upper endoscopy was performed at 3, 6, and 12 month, and yearly thereafter. All patients regenerated squamous epithelium at 6 months. One patient developed a recurrence of Barrett's epithelium 2 years after resection. No recurrences of high-grade dysplasia or carcinoma were observed in any of the patients. Two patients developed an esophageal stricture; both were treated successfully with endoscopic balloon dilation and have suffered no further sequelae. CONCLUSIONS: LTEMR is safe and effective alternative method to treat patients with Barrett's esophagus with high-grade dysplasia.
BACKGROUND: We present long-term follow-up data on patients with esophageal high-grade dysplasia and/or carcinoma in situ who were treated with laparoscopic transgastric esophageal mucosal resection (LTEMR). METHODS:Patient demographics, operative outcomes, and follow-up results were tabulated. RESULTS: LTEMR was performed in 11 patients (9 male, 2 female). The median age was 54 (44 to 75) years. The 30-day morbidity or mortality was zero. The median follow-up was 5.2 (2 to 12) years. Upper endoscopy was performed at 3, 6, and 12 month, and yearly thereafter. All patients regenerated squamous epithelium at 6 months. One patient developed a recurrence of Barrett's epithelium 2 years after resection. No recurrences of high-grade dysplasia or carcinoma were observed in any of the patients. Two patients developed an esophageal stricture; both were treated successfully with endoscopic balloon dilation and have suffered no further sequelae. CONCLUSIONS: LTEMR is safe and effective alternative method to treat patients with Barrett's esophagus with high-grade dysplasia.
Authors: Daniel C Steinemann; Andreas Zerz; Philip C Müller; Peter Sauer; Anja Schaible; Felix Lasitschka; Anne-Catherine Schwarz; Beat P Müller-Stich; Georg R Linke Journal: Endoscopy Date: 2017-03-16 Impact factor: 10.093