BACKGROUND: Previous studies in adults have suggested that donor dopamine treatment may improve recipient outcomes in organ transplantation; in this analysis, we aimed to determine if donor dopamine reduces the incidence of postoperative right heart failure (RHF) in pediatric heart transplant recipients. METHODS: Data for recipients aged 18 years or younger transplanted at our institution between January 1, 2000, and June 15, 2011, and their respective donors were obtained. The presence of postoperative RHF was assessed for in all subjects. Donor dopamine dose was stratified into 3 groups: none, low-dose (≤5 μg/kg per minute), and high-dose (>5 μg/kg per minute). Logistic regression was used to assess the relationship between donor dopamine dose and recipient RHF. RESULTS: Of 192 recipients, 34 (18%) experienced postoperative RHF. There was no difference in baseline demographics between recipients with and without RHF. When controlling for pulmonary vascular resistance index, graft ischemic time, and cardiopulmonary bypass time, donor low-dose dopamine was independently associated with a decreased risk of RHF (odds ratio, 0.16; 95% confidence interval, 0.04-0.70; P = 0.02); however high-dose dopamine was neither associated with, nor protective of, RHF (odds ratio, 0.31; 95% confidence interval, 0.06-1.6; P = 0.16). CONCLUSIONS: Despite advances in perioperative care of the recipient, RHF persists as a complication of pediatric heart transplantation. In this study, donor pretreatment with low-dose dopamine is associated with a decreased risk of postoperative RHF in pediatric heart recipients. Further studies into this association may be useful in determining the utility of empiric donor pretreatment with low-dose dopamine.
BACKGROUND: Previous studies in adults have suggested that donordopamine treatment may improve recipient outcomes in organ transplantation; in this analysis, we aimed to determine if donordopamine reduces the incidence of postoperative right heart failure (RHF) in pediatric heart transplant recipients. METHODS: Data for recipients aged 18 years or younger transplanted at our institution between January 1, 2000, and June 15, 2011, and their respective donors were obtained. The presence of postoperative RHF was assessed for in all subjects. Donordopamine dose was stratified into 3 groups: none, low-dose (≤5 μg/kg per minute), and high-dose (>5 μg/kg per minute). Logistic regression was used to assess the relationship between donordopamine dose and recipient RHF. RESULTS: Of 192 recipients, 34 (18%) experienced postoperative RHF. There was no difference in baseline demographics between recipients with and without RHF. When controlling for pulmonary vascular resistance index, graft ischemic time, and cardiopulmonary bypass time, donor low-dose dopamine was independently associated with a decreased risk of RHF (odds ratio, 0.16; 95% confidence interval, 0.04-0.70; P = 0.02); however high-dose dopamine was neither associated with, nor protective of, RHF (odds ratio, 0.31; 95% confidence interval, 0.06-1.6; P = 0.16). CONCLUSIONS: Despite advances in perioperative care of the recipient, RHF persists as a complication of pediatric heart transplantation. In this study, donor pretreatment with low-dose dopamine is associated with a decreased risk of postoperative RHF in pediatric heart recipients. Further studies into this association may be useful in determining the utility of empiric donor pretreatment with low-dose dopamine.
Authors: Anne I Dipchand; Richard Kirk; Leah B Edwards; Anna Y Kucheryavaya; Christian Benden; Jason D Christie; Fabienne Dobbels; Lars H Lund; Axel O Rahmel; Roger D Yusen; Josef Stehlik Journal: J Heart Lung Transplant Date: 2013-10 Impact factor: 10.247
Authors: George Ofori-Amanfo; Daphne Hsu; Jacqueline M Lamour; Seema Mital; Michael L O'Byrne; Arthur J Smerling; Jonathan M Chen; Ralph Mosca; Linda J Addonizio Journal: J Heart Lung Transplant Date: 2011-01-22 Impact factor: 10.247
Authors: Urs Benck; Simone Hoeger; Paul T Brinkkoetter; Uwe Gottmann; Duygu Doenmez; Detlef Boesebeck; Werner Lauchart; Jan Gummert; Matthias Karck; Hans B Lehmkuhl; Hartmuth B Bittner; Andreas Zuckermann; Florian Wagner; Uwe Schulz; Achim Koch; Amir K Bigdeli; Christoph Bara; Stephan Hirt; Michael Berchtold-Herz; Stefan Brose; Ulf Herold; Johannes Boehm; Henryk Welp; Thomas Strecker; Andreas Doesch; Rainer Birck; Bernhard K Krämer; Benito A Yard; Peter Schnuelle Journal: J Am Coll Cardiol Date: 2011-10-18 Impact factor: 24.094
Authors: Jennifer Conway; Clifford Chin; Mariska Kemna; Michael Burch; Aliessa Barnes; Margaret Tresler; Janet N Scheel; David C Naftel; Kimberly Beddow; Tina Allain-Rooney; Anne I Dipchand Journal: Pediatr Transplant Date: 2013-09-18
Authors: Peter Schnuelle; Uwe Gottmann; Simone Hoeger; Detlef Boesebeck; Werner Lauchart; Christel Weiss; Michael Fischereder; Karl-Walter Jauch; Uwe Heemann; Martin Zeier; Christian Hugo; Przemyslaw Pisarski; Bernhard K Krämer; Kai Lopau; Axel Rahmel; Urs Benck; Rainer Birck; Benito Antonio Yard Journal: JAMA Date: 2009-09-09 Impact factor: 56.272
Authors: Jennifer Huang; Kim Trinkaus; Charles B Huddleston; Eric N Mendeloff; Thomas L Spray; Charles E Canter Journal: J Heart Lung Transplant Date: 2004-06 Impact factor: 10.247
Authors: Koen D W Hendriks; Isabel M A Brüggenwirth; Hanno Maassen; Albert Gerding; Barbara Bakker; Robert J Porte; Robert H Henning; Henri G D Leuvenink Journal: J Transl Med Date: 2019-08-13 Impact factor: 5.531