Literature DB >> 26783998

DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines.

Dulamsuren Oktyabri1, Akihiko Ishimura2, Shoichiro Tange1, Minoru Terashima1, Takeshi Suzuki3.   

Abstract

DOT1L is a histone H3 lysine 79 (H3K79) methyltransferase mainly implicated in leukemia. Here we analyzed the function of DOT1L in breast cancer cells. The expression of DOT1L was up-regulated in malignant breast cancer tissues. Over-expression of DOT1L significantly increased the sphere formation and the cell migration activities of MCF7 breast cancer cell line. In contrast, knockdown of DOT1L reduced the cell migration activity of MDA-MB-231 breast cancer cell line. BCAT1, which encodes a branched-chain amino acid transaminase, was identified as one of the target genes controlled by DOT1L through the regulation of H3K79 methylation. Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L-mediated sphere formation and cell migration in breast cancer cells.
Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Entities:  

Keywords:  Cancer progression; Cell migration; Histone methyltransferase; Sphere formation; Transcriptional regulation

Mesh：

Substances：

Year:  2016        PMID： 26783998     DOI： 10.1016/j.biochi.2016.01.005

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  21 in total

1.  MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines.

Authors:  Minoru Terashima; Shoichiro Tange; Akihiko Ishimura; Takeshi Suzuki
Journal:  J Biol Chem       Date:  2016-11-16       Impact factor: 5.157

2.  BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation.

Authors:  Mengdan Yu; Qianwei Zhao; Jinxia Li; Fang Xu; Zhibiao Zhang; Yixian Liu; Liping Dai; Bingxia Zhang; Jianying Zhang; Jintao Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2022 Sept 15       Impact factor: 5.552

3.  Branched Chain Amino Acids.

Authors:  Michael Neinast; Danielle Murashige; Zoltan Arany
Journal:  Annu Rev Physiol       Date:  2018-11-28       Impact factor: 19.318

4.  Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.

Authors:  Garrett S Gibbons; Amarraj Chakraborty; Sierrah M Grigsby; Afoma C Umeano; Chenzhong Liao; Omar Moukha-Chafiq; Vibha Pathak; Bini Mathew; Young-Tae Lee; Yali Dou; Stephan C Schürer; Robert C Reynolds; Timothy S Snowden; Zaneta Nikolovska-Coleska
Journal:  Eur J Med Chem       Date:  2020-01-02       Impact factor: 6.514

5.  Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer.

Authors:  Xiaoxue Zhang; Dan Liu; Mengchen Li; Canhui Cao; Dongyi Wan; Bixin Xi; Wenqian Li; Jiahong Tan; Ji Wang; Zhongcai Wu; Ding Ma; Qinglei Gao
Journal:  J Hematol Oncol       Date:  2017-01-23       Impact factor: 17.388

6.  Copy-number variation and protein expression of DOT1L in pancreatic adenocarcinoma as a potential drug target.

Authors:  Heike Loeser; Dirk Waldschmidt; Fabian Kuetting; Carina Heydt; Thomas Zander; Patrick Plum; Hakan Alakus; Reinhard Buettner; Alexander Quaas
Journal:  Mol Clin Oncol       Date:  2017-03-14

7.  Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer.

Authors:  Yu Song; Bin Zhao; Yali Xu; Xinyu Ren; Yan Lin; Liangrui Zhou; Qiang Sun
Journal:  BMC Cancer       Date:  2020-06-22       Impact factor: 4.430

8.  Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma.

Authors:  Elitsa A Ananieva; Joshua N Bostic; Ashley A Torres; Hannah R Glanz; Sean M McNitt; Michelle K Brenner; Michael P Boyer; Adele K Addington; Susan M Hutson
Journal:  Br J Cancer       Date:  2018-10-15       Impact factor: 7.640

Review 9.  Branched-chain amino acid metabolism in cancer.

Authors:  Elitsa A Ananieva; Adam C Wilkinson
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2018-01       Impact factor: 4.294

10.  Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma.

Authors:  Yang Qu; Li Liu; Jiajun Wang; Wei Xi; Yu Xia; Qi Bai; Ying Xiong; Qilai Long; Jiejie Xu; Jianming Guo
Journal:  Oncotarget       Date:  2016-12-20
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