Iris Krishna1, Martina Badell1, Tammy L Loucks1, Michael Lindsay1, Amber Samuel2. 1. Department of Gynecology and Obstetrics, Division of Maternal-Fetal Medicine, Emory University School of Medicine, Atlanta, GA, USA. 2. Maternal-Fetal Medicine, Obstetrix Medical Group of Houston, The Woodlands, TX, USA.
Abstract
OBJECTIVE: This study aimed to assess risk of an adverse perinatal outcome for women with a low fetal fraction (LFF) result on noninvasive prenatal testing (NIPT). STUDY DESIGN: A retrospective cohort study whereby women with an LFF result were compared with women who had a sufficient fetal fraction (SFF) result on NIPT. Inclusion criteria were singleton pregnancies with quantification of fetal fraction and pregnancy outcome information. Primary outcome was a composite of any of the following: miscarriage, fetal demise, neonatal death, preterm birth, pregnancy-associated hypertensive disorder, placental abruption, and low birth weight. RESULTS: Three hundred forty-eight (94%) women had an SFF result, and 22 (6%) women had an LFF result. The mean gestational age at the time of NIPT was comparable for both groups. Women with an LFF result were more likely to be African American (86% vs 52%; p = 0.007) and have a higher body mass index (BMI) (mean BMI = 37 kg/m(2) vs BMI = 29 kg/m(2) ; p ≤ 0.001) than women with an SFF result. The composite outcome was significantly more common in the LFF group (59.1% vs 29%; p = 0.003). After adjusting for race and BMI, LFF remained independently associated with adverse perinatal outcome with adjusted odds ratio = 2.5 (95% confidence interval 1.01-6.2; p = 0.049). CONCLUSIONS: Women with an LFF result have an increased likelihood of an adverse pregnancy outcome.
OBJECTIVE: This study aimed to assess risk of an adverse perinatal outcome for women with a low fetal fraction (LFF) result on noninvasive prenatal testing (NIPT). STUDY DESIGN: A retrospective cohort study whereby women with an LFF result were compared with women who had a sufficient fetal fraction (SFF) result on NIPT. Inclusion criteria were singleton pregnancies with quantification of fetal fraction and pregnancy outcome information. Primary outcome was a composite of any of the following: miscarriage, fetal demise, neonatal death, preterm birth, pregnancy-associated hypertensive disorder, placental abruption, and low birth weight. RESULTS: Three hundred forty-eight (94%) women had an SFF result, and 22 (6%) women had an LFF result. The mean gestational age at the time of NIPT was comparable for both groups. Women with an LFF result were more likely to be African American (86% vs 52%; p = 0.007) and have a higher body mass index (BMI) (mean BMI = 37 kg/m(2) vs BMI = 29 kg/m(2) ; p ≤ 0.001) than women with an SFF result. The composite outcome was significantly more common in the LFF group (59.1% vs 29%; p = 0.003). After adjusting for race and BMI, LFF remained independently associated with adverse perinatal outcome with adjusted odds ratio = 2.5 (95% confidence interval 1.01-6.2; p = 0.049). CONCLUSIONS:Women with an LFF result have an increased likelihood of an adverse pregnancy outcome.
Authors: Ellis C Becking; Soetinah A M Wirjosoekarto; Peter G Scheffer; Julia V M Huiskes; Marinka J Remmelink; Erik A Sistermans; Caroline J Bax; Janneke M Weiss; Lidewij Henneman; Mireille N Bekker Journal: Prenat Diagn Date: 2021-09-09 Impact factor: 3.242
Authors: Peter G Scheffer; Soetinah A M Wirjosoekarto; Ellis C Becking; Marjan M Weiss; Caroline J Bax; Dick Oepkes; Erik A Sistermans; Lidewij Henneman; Mireille N Bekker Journal: Prenat Diagn Date: 2021-08-18 Impact factor: 3.242