Literature DB >> 26783567

Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets.

F Meyer1.   

Abstract

Recent advances regarding the synthetic chemistry of fluorinated aziridines, azetidines, pyrrolidines and their lactam/amino acid counterparts are presented. These heterocycles are of high importance both as building blocks for more complex structures and as active parts of medicinal chemistry-oriented compounds.

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Year:  2016        PMID： 26783567     DOI： 10.1039/c5cc09414c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Cyclometalated Iridium-PhanePhos Complexes Are Active Catalysts in Enantioselective Allene-Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters.

Authors:  Leyah A Schwartz; Michael Holmes; Gilmar A Brito; Théo P Gonçalves; Jeffery Richardson; J Craig Ruble; Kuo-Wei Huang; Michael J Krische
Journal:  J Am Chem Soc       Date:  2019-01-25       Impact factor: 15.419

Review 2.  Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives.

Authors:  Sarah Rioton; Domingo Gomez Pardo; Janine Cossy
Journal:  Molecules       Date:  2017-03-19       Impact factor: 4.411

3.  Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines.

Authors:  Laura Ielo; Saad Touqeer; Alexander Roller; Thierry Langer; Wolfgang Holzer; Vittorio Pace
Journal:  Angew Chem Int Ed Engl       Date:  2019-01-24       Impact factor: 15.336

4.  Two Catalytic Annulation Modes via Cu-Allenylidenes with Sulfur Ylides that Are Dominated by the Presence or Absence of Trifluoromethyl Substituents.

Authors:  Malla Reddy Gannarapu; Jun Zhou; Bingyao Jiang; Norio Shibata
Journal:  iScience       Date:  2020-03-20

5.  Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis.

Authors:  Xing-Fa Tan; Fa-Guang Zhang; Jun-An Ma
Journal:  Beilstein J Org Chem       Date:  2020-04-07       Impact factor: 2.883

6.  Controllable access to trifluoromethyl-containing indoles and indolines: palladium-catalyzed regioselective functionalization of unactivated alkenes with trifluoroacetimidoyl chlorides.

Authors:  Hefei Yang; Le-Cheng Wang; Yu Zhang; Dongling Zheng; Zhengkai Chen; Xiao-Feng Wu
Journal:  Chem Sci       Date:  2022-03-03       Impact factor: 9.825

7.  Thioether-functionalized trifluoromethyl-alkynes, 1,3-dienes and allenes: divergent synthesis from reaction of 2-trifluoromethyl-1,3-conjugated enynes with sulfur nucleophiles.

Authors:  Huayu Cheng; Xiaofan Zhou; Anjing Hu; Shiteng Ding; Yimo Wang; Yuanjing Xiao; Junliang Zhang
Journal:  RSC Adv       Date:  2018-10-04       Impact factor: 4.036

8.  First Example of Fluorinated Phenanthroline Diamides: Synthesis, Structural Study, and Complexation with Lanthanoids.

Authors:  Nane A Avagyan; Pavel S Lemport; Konstantin A Lysenko; Alexey O Gudovannyy; Vitaly A Roznyatovsky; Valentine S Petrov; Mikhail F Vokuev; Yuri A Ustynyuk; Valentine G Nenajdenko
Journal:  Molecules       Date:  2022-07-23       Impact factor: 4.927

9.  Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)-Enol Esters.

Authors:  Guangyuan Liu; Xingxing Zhang; Guanghua Kuang; Naihao Lu; Yang Fu; Yiyuan Peng; Qiang Xiao; Yirong Zhou
Journal:  ACS Omega       Date:  2020-02-20
  9 in total

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