Patricia M Dehon1, Michael E Hagensee2, Kimberly J Sutton1, Hope E Oddo1, Nia Nelson1, Chris L McGowin2. 1. Department of Microbiology, Immunology, and Parasitology. 2. Department of Microbiology, Immunology, and Parasitology Section of Infectious Diseases, Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans.
Abstract
BACKGROUND: Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in inflammatory syndromes of the female reproductive tract. The objective of this study was to investigate human immunodeficiency virus (HIV)-infected women for an association between M. genitalium and cervicitis, a putative mechanism for enhanced HIV transmission efficiency to an uninfected partner. METHODS: Using a longitudinal cohort of antiretroviral therapy-adherent New Orleans women, we retrospectively screened for M. genitalium and quantitatively characterized several markers of cervical inflammation, including secreted cytokines and cytological and histological signs of leukocyte infiltration. RESULTS: We observed a high prevalence of M. genitalium (7.4%) among HIV-infected New Orleans women. Chronic M. genitalium infection was associated with increased secretion of proinflammatory cytokines, including interleukin 1β, interleukin 6, and interleukin 8, and marked inflammatory cervical infiltrates in the cervix with enrichment of HIV target cells. Cure of M. genitalium infection resulted in ablation of all signs of inflammation. CONCLUSIONS: These findings implicate M. genitalium as an etiologic agent of cervicitis in HIV-infected women, providing a potential mechanism for enhanced HIV transmission to an uninfected partner. Screening and treatment of M. genitalium among HIV-infected individuals may be warranted to further understand this coinfection scenario, improve cervical health, and reduce the spread of HIV.
BACKGROUND:Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in inflammatory syndromes of the female reproductive tract. The objective of this study was to investigate human immunodeficiency virus (HIV)-infectedwomen for an association between M. genitalium and cervicitis, a putative mechanism for enhanced HIV transmission efficiency to an uninfected partner. METHODS: Using a longitudinal cohort of antiretroviral therapy-adherent New Orleans women, we retrospectively screened for M. genitalium and quantitatively characterized several markers of cervical inflammation, including secreted cytokines and cytological and histological signs of leukocyte infiltration. RESULTS: We observed a high prevalence of M. genitalium (7.4%) among HIV-infected New Orleans women. Chronic M. genitaliuminfection was associated with increased secretion of proinflammatory cytokines, including interleukin 1β, interleukin 6, and interleukin 8, and marked inflammatory cervical infiltrates in the cervix with enrichment of HIV target cells. Cure of M. genitaliuminfection resulted in ablation of all signs of inflammation. CONCLUSIONS: These findings implicate M. genitalium as an etiologic agent of cervicitis in HIV-infectedwomen, providing a potential mechanism for enhanced HIV transmission to an uninfected partner. Screening and treatment of M. genitalium among HIV-infected individuals may be warranted to further understand this coinfection scenario, improve cervical health, and reduce the spread of HIV.
Authors: M Gatski; D H Martin; K Theall; A Amedee; R A Clark; J Dumestre; P Chhabra; N Schmidt; P Kissinger Journal: Int J STD AIDS Date: 2011-03 Impact factor: 1.359
Authors: Lisa E Manhart; Catherine W Gillespie; M Sylvan Lowens; Christine M Khosropour; Danny V Colombara; Matthew R Golden; Navneet R Hakhu; Katherine K Thomas; James P Hughes; Nicole L Jensen; Patricia A Totten Journal: Clin Infect Dis Date: 2012-12-07 Impact factor: 9.079
Authors: Chris L McGowin; Rochelle S Annan; Alison J Quayle; Sheila J Greene; Liang Ma; Miriam M Mancuso; David Adegboye; David H Martin Journal: Infect Immun Date: 2012-08-20 Impact factor: 3.441
Authors: Julie L Ryan; Hongxin Fan; Lode J Swinnen; Steven A Schichman; Nancy Raab-Traub; Mary Covington; Sandra Elmore; Margaret L Gulley Journal: Diagn Mol Pathol Date: 2004-06
Authors: Jennifer E Cameron; Anne F Rositch; Nadja A Vielot; Nelly R Mugo; Jessie K L Kwatampora; Wairimu Waweru; Aubrey E Gilliland; Michael E Hagensee; Jennifer S Smith Journal: Sex Transm Dis Date: 2018-10 Impact factor: 2.830
Authors: Brandie D Taylor; Xiaojing Zheng; Catherine M O'Connell; Harold C Wiesenfeld; Sharon L Hillier; Toni Darville Journal: Sex Transm Infect Date: 2018-03-21 Impact factor: 3.519
Authors: Laarni Kendra T Aguila; Dorothy L Patton; German G Gornalusse; Lucia N Vojtech; Robert D Murnane; Gwendolyn E Wood Journal: Infect Immun Date: 2022-05-18 Impact factor: 3.609
Authors: Barbara Van Der Pol; Ken B Waites; Li Xiao; Stephanie N Taylor; Arundhati Rao; Melinda Nye; Steven Chavoustie; Aaron Ermel; Clair Kaplan; David Eisenberg; Philip A Chan; Leandro Mena; Sixto Pacheco; Smitha Krishnamurthy; Ruchika Mohan; Rasa Bertuzis; Chris L McGowin; Rodney Arcenas; Elizabeth M Marlowe Journal: J Clin Microbiol Date: 2020-05-26 Impact factor: 5.948
Authors: Cameron Klein; Crispin Kahesa; Julius Mwaiselage; John T West; Charles Wood; Peter C Angeletti Journal: Front Cell Infect Microbiol Date: 2020-02-12 Impact factor: 5.293