Literature DB >> 26782638

Human Mesenchymal Stem Cell Delivery System Modulates Ischemic Cardiac Remodeling With an Increase of Coronary Artery Blood Flow.

Young Sook Lee1, Wan Seok Joo2, Hyun Soo Kim2, Sung Wan Kim1,3.   

Abstract

Ways for extending the longevity of stem cells are imperative to attain diverse expected therapeutic effects. Here, we constructed a three-dimentional (3D) scaffold system for human mesenchymal stem cell (hMSC) delivery. Intramyocardial injections of porous PEI1.8k blended with poly(lactic-co-glycolic acid) (PLGA) (PLGA/PEI1.8k) (PPP) microparticles by physical electrostatic conjugation and structural entrapment of hMSCs demonstrated enhanced functional and geometric improvements on post-infarct cardiac remodeling in rats. In the hMSC-loaded PPP delivery, increases of coronary artery blood flow rate and in vivo engraftment rate as well as time-dependent functional, geometric, and pathologic findings reversing post-infarct cardiac remodeling account for improved left ventricular (LV) systolic function up to the level of sham thoracotomy group. This study expands our understanding by proving that increase of coronary artery blood flow augmented functional recovery of hMSC-loaded PPP delivery system after myocardial infarction (MI).

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26782638      PMCID： PMC4886938          DOI： 10.1038/mt.2016.22

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


  35 in total

1.  Impact of coronary microvascular function on long-term cardiac mortality in patients with acute ST-segment-elevation myocardial infarction.

Authors:  Tim P van de Hoef; Matthijs Bax; Martijn Meuwissen; Peter Damman; Ronak Delewi; Robbert J de Winter; Karel T Koch; Carl Schotborgh; José P S Henriques; Jan G P Tijssen; Jan J Piek
Journal:  Circ Cardiovasc Interv       Date:  2013-06-04       Impact factor: 6.546

2.  Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography.

Authors:  T Hozumi; K Yoshida; Y Ogata; T Akasaka; Y Asami; T Takagi; S Morioka
Journal:  Circulation       Date:  1998-04-28       Impact factor: 29.690

Review 3.  Role of positron emission tomography in the investigation of human coronary circulatory function.

Authors:  R de Silva; P G Camici
Journal:  Cardiovasc Res       Date:  1994-11       Impact factor: 10.787

4.  Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.

Authors:  C J Murray; A D Lopez
Journal:  Lancet       Date:  1997-05-24       Impact factor: 79.321

Review 5.  Controversies in ventricular remodelling.

Authors:  Lionel H Opie; Patrick J Commerford; Bernard J Gersh; Marc A Pfeffer
Journal:  Lancet       Date:  2006-01-28       Impact factor: 79.321

Review 6.  Mesenchymal stem cells as therapeutics.

Authors:  Biju Parekkadan; Jack M Milwid
Journal:  Annu Rev Biomed Eng       Date:  2010-08-15       Impact factor: 9.590

7.  Influence of poly(D,L-lactic-co-glycolic acid) microsphere degradation on arteriolar remodeling in the mouse dorsal skinfold window chamber.

Authors:  Meghan M Nickerson; Ji Song; Casey W Shuptrine; Kristen A Wieghaus; Edward A Botchwey; Richard J Price
Journal:  J Biomed Mater Res A       Date:  2009-11       Impact factor: 4.396

Review 8.  Coronary artery bypass graft surgery vs percutaneous interventions in coronary revascularization: a systematic review.

Authors:  Saswata Deb; Harindra C Wijeysundera; Dennis T Ko; Hideki Tsubota; Samantha Hill; Stephen E Fremes
Journal:  JAMA       Date:  2013-11-20       Impact factor: 56.272

Review 9.  Growing epidemic of coronary heart disease in low- and middle-income countries.

Authors:  Thomas A Gaziano; Asaf Bitton; Shuchi Anand; Shafika Abrahams-Gessel; Adrianna Murphy
Journal:  Curr Probl Cardiol       Date:  2010-02       Impact factor: 5.200

Review 10.  In search of new therapeutic targets and strategies for heart failure: recent advances in basic science.

Authors:  Ajay M Shah; Douglas L Mann
Journal:  Lancet       Date:  2011-08-20       Impact factor: 79.321
View more
  4 in total

Review 1.  Can the outcomes of mesenchymal stem cell-based therapy for myocardial infarction be improved? Providing weapons and armour to cells.

Authors:  Andrey A Karpov; Daria V Udalova; Michael G Pliss; Michael M Galagudza
Journal:  Cell Prolif       Date:  2016-11-23       Impact factor: 6.831

2.  Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats.

Authors:  Young Sook Lee; Joung-Woo Choi; Jung-Eun Oh; Chae-Ok Yun; Sung Wan Kim
Journal:  Biomaterials       Date:  2016-04-26       Impact factor: 12.479

3.  PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction.

Authors:  Panke Cheng; Wen Zeng; Li Li; Da Huo; Lingqing Zeng; Ju Tan; Jingting Zhou; Jiansen Sun; Ge Liu; Yanzhao Li; Ge Guan; Yuxin Wang; Chuhong Zhu
Journal:  Adv Sci (Weinh)       Date:  2016-10-24       Impact factor: 16.806

4.  Scaffold-based lung tumor culture on porous PLGA microparticle substrates.

Authors:  Aneetta E Kuriakose; Wenjing Hu; Kytai T Nguyen; Jyothi U Menon
Journal:  PLoS One       Date:  2019-05-31       Impact factor: 3.240
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.