Robert W Motl1, Robert Zivadinov2,3, Niels Bergsland2,4, Ralph H B Benedict5. 1. Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. 2. Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. 3. MR Imaging Clinical Translational Research Center, School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. 4. IRCCS 'Santa Maria Nascente', Don Gnocchi Foundation, Milan, Italy. 5. Department of Neurology, School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Abstract
AIM: This cross-sectional study examined if subcortical gray matter (SGM) structures accounted for differences in timed 25-foot walk (T25FW) speed between multiple sclerosis (MS) patients and controls. METHODS: Subjects underwent brain MRI and completed the T25FW. Volumes of the thalamus, caudate, putamen and pallidum were calculated from 3D T1-weighted structural brain images. T2 lesion volume (T2LV) was determined by using a semiautomated edge detection contouring-thresholding technique. RESULTS: There were differences in T25FW speed, SGM volumes and T2LV between MS and controls. T25FW speed was associated with SGM volumes and T2LV in MS and controls. Thalamic volume partially accounted for the difference in T25FW speed between the MS and controls. CONCLUSION: The reduction of thalamus volume is associated with compromised ambulation in MS patients.
AIM: This cross-sectional study examined if subcortical gray matter (SGM) structures accounted for differences in timed 25-foot walk (T25FW) speed between multiple sclerosis (MS) patients and controls. METHODS: Subjects underwent brain MRI and completed the T25FW. Volumes of the thalamus, caudate, putamen and pallidum were calculated from 3D T1-weighted structural brain images. T2 lesion volume (T2LV) was determined by using a semiautomated edge detection contouring-thresholding technique. RESULTS: There were differences in T25FW speed, SGM volumes and T2LV between MS and controls. T25FW speed was associated with SGM volumes and T2LV in MS and controls. Thalamic volume partially accounted for the difference in T25FW speed between the MS and controls. CONCLUSION: The reduction of thalamus volume is associated with compromised ambulation in MSpatients.
Authors: Hrishikesh Lokhande; Mattia Rosso; Shahamat Tauhid; Renxin Chu; Brian C Healy; Shrishti Saxena; Christian Barro; Anu Paul; Mariann Polgar-Turcsanyi; Mark Anderson; Bonnie I Glanz; Harald Kropshofer; Cristina Granziera; David Leppert; Ludwig Kappos; Jens Kuhle; Howard L Weiner; Rohit Bakshi; Tanuja Chitnis Journal: Mult Scler J Exp Transl Clin Date: 2022-01-10
Authors: Gilles Allali; Helena M Blumen; Hervé Devanne; Elvira Pirondini; Arnaud Delval; Dimitri Van De Ville Journal: Neurophysiol Clin Date: 2018-10-25 Impact factor: 3.734