Literature DB >> 26782118

PITX2: a master regulator of cardiac channelopathy in atrial fibrillation?

Na Li1, Dobromir Dobrev2, Xander H T Wehrens3.   

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Year:  2016        PMID： 26782118      PMCID： PMC4752046          DOI： 10.1093/cvr/cvw008

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


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  15 in total

1.  Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.

Authors:  Jun Wang; Elzbieta Klysik; Subeena Sood; Randy L Johnson; Xander H T Wehrens; James F Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-10       Impact factor: 11.205

2.  PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.

Authors:  Ana Chinchilla; Houria Daimi; Estefanía Lozano-Velasco; Jorge N Dominguez; Ricardo Caballero; Eva Delpón; Juan Tamargo; Juan Cinca; Leif Hove-Madsen; Amelia E Aranega; Diego Franco
Journal:  Circ Cardiovasc Genet       Date:  2011-04-21

3.  PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.

Authors:  Paulus Kirchhof; Peter C Kahr; Sven Kaese; Ilaria Piccini; Ismail Vokshi; Hans-Heinrich Scheld; Heinrich Rotering; Lisa Fortmueller; Sandra Laakmann; Sander Verheule; Ulrich Schotten; Larissa Fabritz; Nigel A Brown
Journal:  Circ Cardiovasc Genet       Date:  2011-01-31

4.  Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.

Authors:  Marylyn D Ritchie; Shane Rowan; Gayle Kucera; Tanya Stubblefield; Marcia Blair; Shannon Carter; Dan M Roden; Dawood Darbar
Journal:  J Am Coll Cardiol       Date:  2012-07-18       Impact factor: 24.094

5.  Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L.

Authors:  Marta Pérez-Hernández; Marcos Matamoros; Adriana Barana; Irene Amorós; Ricardo Gómez; Mercedes Núñez; Sandra Sacristán; Ángel Pinto; Francisco Fernández-Avilés; Juan Tamargo; Eva Delpón; Ricardo Caballero
Journal:  Cardiovasc Res       Date:  2015-12-28       Impact factor: 10.787

6.  Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes.

Authors:  Ye Tao; Min Zhang; Lele Li; Yan Bai; Yuefang Zhou; Anne M Moon; Henry J Kaminski; James F Martin
Journal:  Circ Cardiovasc Genet       Date:  2014-01-06

7.  Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese.

Authors:  Steven A Lubitz; Kathryn L Lunetta; Honghuang Lin; Dan E Arking; Stella Trompet; Guo Li; Bouwe P Krijthe; Daniel I Chasman; John Barnard; Marcus E Kleber; Marcus Dörr; Kouichi Ozaki; Albert V Smith; Martina Müller-Nurasyid; Stefan Walter; Joanne M Murabito; Moritz F Sinner; Vilmundur Gudnason; Stephan B Felix; Winfried März; Mina Chung; Christine M Albert; Bruno H Stricker; Toshihiro Tanaka; Susan R Heckbert; J Wouter Jukema; Alvaro Alonso; Emelia J Benjamin; Patrick T Ellinor; Sunil K Agarwal; Joshua C Bis; Jennifer A Brody; Lin Y Chen; Brendan M Everett; Ian Ford; Oscar H Franco; Tamara B Harris; Albert Hofman; Stefan Kääb; Saagar Mahida; Sekar Kathiresan; Michiaki Kubo; Lenore J Launer; Peter W MacFarlane; Jared W Magnani; Barbara McKnight; David D McManus; Annette Peters; Bruce M Psaty; Lynda M Rose; Jerome I Rotter; Guenther Silbernagel; Jonathan D Smith; Nona Sotoodehnia; David J Stott; Kent D Taylor; Andreas Tomaschitz; Tatsuhiko Tsunoda; Andre G Uitterlinden; David R Van Wagoner; Uwe Völker; Henry Völzke
Journal:  J Am Coll Cardiol       Date:  2014-01-30       Impact factor: 24.094

8.  Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

Authors:  Patrick T Ellinor; Kathryn L Lunetta; Christine M Albert; Nicole L Glazer; Marylyn D Ritchie; Albert V Smith; Dan E Arking; Martina Müller-Nurasyid; Bouwe P Krijthe; Steven A Lubitz; Joshua C Bis; Mina K Chung; Marcus Dörr; Kouichi Ozaki; Jason D Roberts; J Gustav Smith; Arne Pfeufer; Moritz F Sinner; Kurt Lohman; Jingzhong Ding; Nicholas L Smith; Jonathan D Smith; Michiel Rienstra; Kenneth M Rice; David R Van Wagoner; Jared W Magnani; Reza Wakili; Sebastian Clauss; Jerome I Rotter; Gerhard Steinbeck; Lenore J Launer; Robert W Davies; Matthew Borkovich; Tamara B Harris; Honghuang Lin; Uwe Völker; Henry Völzke; David J Milan; Albert Hofman; Eric Boerwinkle; Lin Y Chen; Elsayed Z Soliman; Benjamin F Voight; Guo Li; Aravinda Chakravarti; Michiaki Kubo; Usha B Tedrow; Lynda M Rose; Paul M Ridker; David Conen; Tatsuhiko Tsunoda; Tetsushi Furukawa; Nona Sotoodehnia; Siyan Xu; Naoyuki Kamatani; Daniel Levy; Yusuke Nakamura; Babar Parvez; Saagar Mahida; Karen L Furie; Jonathan Rosand; Raafia Muhammad; Bruce M Psaty; Thomas Meitinger; Siegfried Perz; H-Erich Wichmann; Jacqueline C M Witteman; W H Linda Kao; Sekar Kathiresan; Dan M Roden; Andre G Uitterlinden; Fernando Rivadeneira; Barbara McKnight; Marketa Sjögren; Anne B Newman; Yongmei Liu; Michael H Gollob; Olle Melander; Toshihiro Tanaka; Bruno H Ch Stricker; Stephan B Felix; Alvaro Alonso; Dawood Darbar; John Barnard; Daniel I Chasman; Susan R Heckbert; Emelia J Benjamin; Vilmundur Gudnason; Stefan Kääb
Journal:  Nat Genet       Date:  2012-04-29       Impact factor: 38.330

9.  Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling.

Authors:  Estefanía Lozano-Velasco; Francisco Hernández-Torres; Houria Daimi; Selma A Serra; Adela Herraiz; Leif Hove-Madsen; Amelia Aránega; Diego Franco
Journal:  Cardiovasc Res       Date:  2015-08-04       Impact factor: 10.787

10.  Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages.

Authors:  Shamone R Gore-Panter; Jeffery Hsu; Peter Hanna; A Marc Gillinov; Gosta Pettersson; David W Newton; Christine S Moravec; David R Van Wagoner; Mina K Chung; John Barnard; Jonathan D Smith
Journal:  PLoS One       Date:  2014-01-22       Impact factor: 3.240
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  3 in total

Review 1.  Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation.

Authors:  Alexander T Mikhailov; Mario Torrado
Journal:  J Mol Med (Berl)       Date:  2018-05-12       Impact factor: 4.599

Review 2.  PITX2-dependent gene regulation in atrial fibrillation and rhythm control.

Authors:  Fahima Syeda; Paulus Kirchhof; Larissa Fabritz
Journal:  J Physiol       Date:  2017-04-25       Impact factor: 5.182

3.  PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers.

Authors:  Fahima Syeda; Andrew P Holmes; Ting Y Yu; Samantha Tull; Stefan Michael Kuhlmann; Davor Pavlovic; Daniel Betney; Genna Riley; Jan P Kucera; Florian Jousset; Joris R de Groot; Stephan Rohr; Nigel A Brown; Larissa Fabritz; Paulus Kirchhof
Journal:  J Am Coll Cardiol       Date:  2016-10-25       Impact factor: 24.094
  3 in total

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