Feng Li1, Han Cao1, Chunjun Sheng1, Hang Sun1, Kexiu Song1, Shen Qu2. 1. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tong-Ji University, 301 Middle Yan-Chang Road, Shanghai, 200072, China. 2. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tong-Ji University, 301 Middle Yan-Chang Road, Shanghai, 200072, China. qushencn@hotmail.com.
Abstract
PURPOSE: Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood. MATERIALS AND METHODS: From February 2014 to July 2015, sleeve gastrectomy was performed in 5 patients with T2D, who were assessed before and after sleeve gastrectomy (SG). Moreover, a high-fat-diet (HFD) mouse model was also used to study the molecular mechanisms of β-cell functional improvement after SG. RESULTS: The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was significantly increased after SG. CONCLUSION: β-cell dysfunction can be ameliorated by SG. The re-activation of key TFs contributes to the improvement of β cell function.
PURPOSE: Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood. MATERIALS AND METHODS: From February 2014 to July 2015, sleeve gastrectomy was performed in 5 patients with T2D, who were assessed before and after sleeve gastrectomy (SG). Moreover, a high-fat-diet (HFD) mouse model was also used to study the molecular mechanisms of β-cell functional improvement after SG. RESULTS: The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was significantly increased after SG. CONCLUSION: β-cell dysfunction can be ameliorated by SG. The re-activation of key TFs contributes to the improvement of β cell function.
Authors: Jean-Philippe Krieger; Myrtha Arnold; Klaus G Pettersen; Pius Lossel; Wolfgang Langhans; Shin J Lee Journal: Diabetes Date: 2015-10-15 Impact factor: 9.461
Authors: Hans Eickhoff; Ana Guimarães; Teresa M Louro; Raquel M Seiça; Francisco Castro E Sousa Journal: Surg Endosc Date: 2014-07-04 Impact factor: 4.584