Literature DB >> 26781255

Ghrelin and Blood Pressure Regulation.

Yuanjie Mao1,2, Takeshi Tokudome2, Ichiro Kishimoto3.   

Abstract

Ghrelin is a growth hormone-releasing polypeptide that was first isolated from the rat stomach in 1999. High expression of growth hormone secretagogue receptor, the ghrelin receptor, in the heart, kidney, and blood vessels provides evidence of ghrelin activity in blood pressure regulation. Circulating ghrelin concentrations are reported to be inversely correlated with blood pressure, and the acute and chronic effects of ghrelin in decreasing blood pressure have been reported in animals with normal blood pressure, healthy individuals, animals and patients with heart failure, and animals with hypertension. The mechanism by which ghrelin regulates blood pressure appears to be related to modulation of the autonomic nervous system, direct vasodilatory activities, and kidney diuresis. Thus, modulation of the signaling pathway through ghrelin may provide a novel concept for treating hypertension. In this review, we discuss the current evidence and potential mechanisms of ghrelin activity in blood pressure regulation.

Entities:  

Keywords:  Autonomic nervous system; Blood pressure; Ghrelin; Hypertension; Treatment

Mesh：

Substances：

Year:  2016        PMID： 26781255     DOI： 10.1007/s11906-015-0622-5

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  53 in total

1.  Ghrelin PYY 3-36 serum changes in left ventricular hypertrophic, insulin-resistant, hypertensive obese patients.

Authors:  Iwona Karcz-Socha; Krystyna Zwirska-Korczala; Marian Zembala; Halina Borgiel-Marek; Konrad Karcz
Journal:  Obes Facts       Date:  2011-10-21       Impact factor: 3.942

2.  Relationship of ghrelin and leptin hormones with body mass index and waist circumference in a random sample of adults.

Authors:  Veronica Monti; Joseph J Carlson; Steven C Hunt; Ted D Adams
Journal:  J Am Diet Assoc       Date:  2006-06

3.  A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

Authors:  D E Cummings; J Q Purnell; R S Frayo; K Schmidova; B E Wisse; D S Weigle
Journal:  Diabetes       Date:  2001-08       Impact factor: 9.461

4.  Hemodynamic and hormonal effects of human ghrelin in healthy volunteers.

Authors:  N Nagaya; M Kojima; M Uematsu; M Yamagishi; H Hosoda; H Oya; Y Hayashi; K Kangawa
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2001-05       Impact factor: 3.619

5.  Cilazapril increases plasma ghrelin concentration in obese patients with arterial hypertension.

Authors:  Aleksander Skoczylas; Marcin Adamczak; Jerzy Chudek; Andrzej Wiecek
Journal:  Endokrynol Pol       Date:  2010 Jan-Feb       Impact factor: 1.582

6.  Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.

Authors:  Tomomi Shiiya; Masamitsu Nakazato; Masanari Mizuta; Yukari Date; Muhtashan S Mondal; Muneki Tanaka; Shin-Ichi Nozoe; Hiroshi Hosoda; Kenji Kangawa; Shigeru Matsukura
Journal:  J Clin Endocrinol Metab       Date:  2002-01       Impact factor: 5.958

7.  Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure.

Authors:  Noritoshi Nagaya; Junji Moriya; Yoshio Yasumura; Masaaki Uematsu; Fumiaki Ono; Wataru Shimizu; Kazuyuki Ueno; Masafumi Kitakaze; Kunio Miyatake; Kenji Kangawa
Journal:  Circulation       Date:  2004-11-29       Impact factor: 29.690

8.  Circulating ghrelin levels in obese women: a possible association with hypertension.

Authors:  Y Oner-Iyidoğan; H Koçak; F Gürdöl; P Oner; H Issever; D Esin
Journal:  Scand J Clin Lab Invest       Date:  2007       Impact factor: 1.713

9.  Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats.

Authors:  Yoshito Shimizu; Noritoshi Nagaya; Yasuhiro Teranishi; Michinori Imazu; Hideya Yamamoto; Tomoki Shokawa; Kenji Kangawa; Nobuoki Kohno; Masao Yoshizumi
Journal:  Biochem Biophys Res Commun       Date:  2003-10-24       Impact factor: 3.575

10.  Testosterone is a strong correlate of ghrelin levels in men and postmenopausal women.

Authors:  Yona Greenman; Vanessa Rouach; Rona Limor; Susan Gilad; Naftali Stern
Journal:  Neuroendocrinology       Date:  2008-08-28       Impact factor: 4.914
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  12 in total

1.  The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes.

Authors:  Allon N Friedman; Junyao Wang; Abdus S Wahed; Neil G Docherty; Erin Fennern; Alfons Pomp; Jonathan Q Purnell; Carel W le Roux; Bruce Wolfe
Journal:  Am J Kidney Dis       Date:  2019-07-19       Impact factor: 8.860

Review 2.  "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.

Authors:  Xi Chen; Jing Dong; Qian Jiao; Xixun Du; Mingxia Bi; Hong Jiang
Journal:  Cell Mol Life Sci       Date:  2022-03-03       Impact factor: 9.261

Review 3.  Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.

Authors:  Jian Yang; Pedro A Jose; Chunyu Zeng
Journal:  J Am Heart Assoc       Date:  2017-03-06       Impact factor: 5.501

Review 4.  Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists.

Authors:  Paula Mosińska; Hubert Zatorski; Martin Storr; Jakub Fichna
Journal:  J Neurogastroenterol Motil       Date:  2017-04-30       Impact factor: 4.924

5.  Ghrelin Levels and Decreased Kidney Function in Patients with Early Stages of Chronic Kidney Disease Against the Background of Obesity.

Authors:  Nataliia Vasylivna Gubina; Iryna Hryhorivna Kupnovytska; Vasyl Hryhorovych Mishchuk; Halyna Dmytrivna Markiv
Journal:  J Med Life       Date:  2020 Oct-Dec

Review 6.  Research progress of ghrelin on cardiovascular disease.

Authors:  Ming-Jie Yuan; Wei Li; Peng Zhong
Journal:  Biosci Rep       Date:  2021-01-29       Impact factor: 3.840

7.  Association between breastfeeding and preeclampsia in parous women: a case -control study.

Authors:  Ishag Adam; Duria A Rayis; Nadiah A ALhabardi; Abdel B A Ahmed; Manal E Sharif; Mustafa I Elbashir
Journal:  Int Breastfeed J       Date:  2021-06-29       Impact factor: 3.461

8.  The effects of body weight loss and gain on arterial hypertension control: an observational prospective study.

Authors:  Peter Sabaka; Andrej Dukat; Jan Gajdosik; Matej Bendzala; Martin Caprnda; Fedor Simko
Journal:  Eur J Med Res       Date:  2017-10-25       Impact factor: 2.175

9.  Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.

Authors:  Angus P Yu; Felix N Ugwu; Bjorn T Tam; Paul H Lee; Vicki Ma; Simon Pang; Angel S Chow; Kenneth K Cheng; Christopher W Lai; Cesar S Wong; Parco M Siu
Journal:  Sci Rep       Date:  2020-03-26       Impact factor: 4.379

10.  Gastric mucosal devitalization improves blood pressure, renin and cardiovascular lipid deposition in a rat model of obesity.

Authors:  Andreas Oberbach; Nadine Schlichting; Yvonne Kullnick; Marco Heinrich; Stefanie Lehmann; Ulf Retschlag; Maik Friedrich; Lea Fayad; Arne Dietrich; Mouen A Khashab; Anthony N Kalloo; Vivek Kumbhari
Journal:  Endosc Int Open       Date:  2019-11-25
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