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Literature DB >> 26781187

Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels.

Stacey C Skaalure¹, Umut Akalp², Franck J Vernerey³, Stephanie J Bryant⁴.

Abstract

Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme-sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.

Entities: Chemical Disease Gene

Keywords: computational models; enzyme degradation; hydrogel; reaction-diffusion; tissue engineering

Mesh：

Substances：

Year: 2016 PMID： 26781187 PMCID： PMC4972608 DOI： 10.1002/adhm.201500728

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

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9. Mathematical model of the role of degradation on matrix development in hydrogel scaffold.

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10. A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.

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3. ^* Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for Use in Cartilage Tissue Engineering.

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5. An in vitro tissue model for screening sustained release of phosphate-based therapeutic attenuation of pathogen-induced proteolytic matrix degradation.

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6. Transient response of nonlinear polymer networks: A kinetic theory.

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7. Spatiotemporal neocartilage growth in matrix-metalloproteinase-sensitive poly(ethylene glycol) hydrogels under dynamic compressive loading: an experimental and computational approach.

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