| Literature DB >> 26780174 |
Hyeonjeong Jeon1, Jihoon Kim2, Yeong Mi Lee2, Jinhwan Kim1, Hyung Woo Choi2, Junseok Lee2, Hyeongmok Park1, Youngnam Kang3, In-San Kim4, Byung-Heon Lee5, Allan S Hoffman6, Won Jong Kim7.
Abstract
This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.Entities:
Keywords: Cyclodextrin; Magnetic-guided drug delivery; Multivalent host-guest chemistry; Paclitaxel; SPION
Mesh：
Substances：
Year: 2016 PMID： 26780174 DOI： 10.1016/j.jconrel.2016.01.006
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776