Ilker Uçkay1, Karim Gariani, Victor Dubois-Ferrière, Domizio Suvà, Benjamin A Lipsky. 1. aService of Infectious Diseases bOrthopedic Surgery Service cService of Diabetology and Endocrinology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Switzerland dDivision of Medical Sciences, University of Oxford, Oxford, UK.
Abstract
PURPOSE OF REVIEW: Diabetes mellitus has reached pandemic levels and will continue to increase worldwide. Physicians and surgeons should know to manage one of its most prevalent complications, the diabetic foot infection (DFI), in a scientifically based and resource-sparing way. We performed a nonsystematic review of recent scientific literature to provide guidance on management of DFIs. RECENT FINDINGS: Studies in the past couple of years provide data on which recommendations for diagnosing and treating DFI are based, especially with validated guidelines and reviews of the microbiology and selected aspects of the complex DFI problem. Recent literature provides approaches to prevention and studies support more conservative surgical treatment. Unfortunately, there have been virtually no new therapeutic molecules, antibiotic regimens, randomized trials, or surgical techniques introduced in the recent past; we briefly discuss how this may change in the future. SUMMARY: Recent scientific evidence on DFI strongly supports the value of multidisciplinary and some new care models, guideline-based management, more preventive approaches, and confirms several established therapeutic concepts. In contrast, there has been almost no new substantial information regarding the optimal antibiotic or surgical management in recent literature.
PURPOSE OF REVIEW: Diabetes mellitus has reached pandemic levels and will continue to increase worldwide. Physicians and surgeons should know to manage one of its most prevalent complications, the diabetic foot infection (DFI), in a scientifically based and resource-sparing way. We performed a nonsystematic review of recent scientific literature to provide guidance on management of DFIs. RECENT FINDINGS: Studies in the past couple of years provide data on which recommendations for diagnosing and treating DFI are based, especially with validated guidelines and reviews of the microbiology and selected aspects of the complex DFI problem. Recent literature provides approaches to prevention and studies support more conservative surgical treatment. Unfortunately, there have been virtually no new therapeutic molecules, antibiotic regimens, randomized trials, or surgical techniques introduced in the recent past; we briefly discuss how this may change in the future. SUMMARY: Recent scientific evidence on DFI strongly supports the value of multidisciplinary and some new care models, guideline-based management, more preventive approaches, and confirms several established therapeutic concepts. In contrast, there has been almost no new substantial information regarding the optimal antibiotic or surgical management in recent literature.
Authors: Roger V Ortines; Haiyun Liu; Lily I Cheng; Taylor S Cohen; Heather Lawlor; Abhishek Gami; Yu Wang; Carly A Dillen; Nathan K Archer; Robert J Miller; Alyssa G Ashbaugh; Bret L Pinsker; Mark C Marchitto; Christine Tkaczyk; C Kendall Stover; Bret R Sellman; Lloyd S Miller Journal: Antimicrob Agents Chemother Date: 2018-02-23 Impact factor: 5.191
Authors: Ilker Uçkay; Benjamin Kressmann; Sarah Malacarne; Anna Toumanova; Jaafar Jaafar; Daniel Lew; Benjamin A Lipsky Journal: BMC Infect Dis Date: 2018-08-02 Impact factor: 3.090
Authors: Steven M Maurer; Zehra S Hepp; Shawna McCallin; Felix W A Waibel; Federico C Romero; Yılmaz Zorman; Benjamin A Lipsky; İlker Uçkay Journal: J Bone Jt Infect Date: 2022-03-25
Authors: Céline S Moret; Madlaina Schöni; Felix W A Waibel; Elin Winkler; Angelina Grest; Bettina S Liechti; Jan Burkhard; Dominique Holy; Martin C Berli; Benjamin A Lipsky; Ilker Uçkay Journal: BMC Res Notes Date: 2022-07-27