Literature DB >> 26779545

Bilateral Idiopathic Solitary Granuloma of the Uveal Tract: Diagnosis and Treatment.

Wonchon Lin1, Robert M Beardsley1, Alison H Skalet1, David J Wilson1, James T Rosenbaum2, Phoebe Lin1.   

Abstract

We present a case of sequential bilateral idiopathic solitary granuloma of the uveal tract in a 51 year-old woman, who underwent enucleation in one eye due to complications of this condition, but was then successfully treated in the contralateral eye with anti-tumor necrosis-alpha therapy followed shortly by intraocular steroids and a steroid-releasing implant. Her visual acuity at its worst was 20/200 due to vitreous haze and cystoid macular edema, but then stabilized after successful treatment with a final visual acuity of 20/25 in her only seeing eye at 1 year follow-up. This represents the first known biopsy-proven case of bilateral idiopathic solitary granuloma, which additionally, has responded favorably to treatment.

Entities:  

Keywords:  Ciliary body granuloma; Infliximab; Necrotizing granulomatous disease; Uveitis

Year:  2015        PMID: 26779545      PMCID: PMC4711913          DOI: 10.4172/2324-8599.1000166

Source DB:  PubMed          Journal:  Int J Ophthalmic Pathol        ISSN: 2324-8599


  6 in total

1.  Infliximab therapy for refractory uveitis: 2-year results of a prospective trial.

Authors:  Eric B Suhler; Justine R Smith; Tracy R Giles; Andreas K Lauer; Michael S Wertheim; Daryl E Kurz; Paul A Kurz; Lyndell Lim; Friederike Mackensen; Terri D Pickard; James T Rosenbaum
Journal:  Arch Ophthalmol       Date:  2009-06

2.  Long-term treatment with infliximab in patients with sarcoidosis.

Authors:  Katrin E Hostettler; Ueli Studler; Michael Tamm; Martin H Brutsche
Journal:  Respiration       Date:  2011-07-29       Impact factor: 3.580

3.  Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature.

Authors:  Akaluck Thatayatikom; Sthorn Thatayatikom; Andrew J White
Journal:  Ann Allergy Asthma Immunol       Date:  2005-09       Impact factor: 6.347

4.  Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.

Authors:  A G Bean; D R Roach; H Briscoe; M P France; H Korner; J D Sedgwick; W J Britton
Journal:  J Immunol       Date:  1999-03-15       Impact factor: 5.422

5.  TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection.

Authors:  Daniel R Roach; Andrew G D Bean; Caroline Demangel; Malcolm P France; Helen Briscoe; Warwick J Britton
Journal:  J Immunol       Date:  2002-05-01       Impact factor: 5.422

6.  Idiopathic solitary granuloma of the uveal tract.

Authors:  C Margo; L E Zimmerman
Journal:  Arch Ophthalmol       Date:  1984-05
  6 in total

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