Literature DB >> 26778673

Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study.

Wing Chung Chang1, Christy Lai Ming Hui2, Sherry Kit Wa Chan3, Edwin Ho Ming Lee2, Eric Yu Hai Chen3.   

Abstract

Previous research investigating the relationships between avolition, cognition and functioning in schizophrenia mostly focused on chronic samples and were cross-sectional in design. Impacts of avolition and cognition on longitudinal functional outcome in first-episode patients are under-studied. We assessed 114 Chinese aged 18-55 years presenting with first-episode schizophrenia-spectrum disorder aiming to identify baseline predictors of 1-year functional outcome. Results showed that both avolition and global cognition independently predicted functioning, with avolition being the strongest predictor above and beyond cognition and other symptom dimensions. Our findings indicate the central role of in determining longitudinal functional status in the early illness stage.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  First episode psychosis; Functioning; Motivational impairment; Negative symptoms

Mesh：

Year:  2016        PMID： 26778673     DOI： 10.1016/j.schres.2016.01.004

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  11 in total

1.  Temporal Lobe Volume Decrements in Psychosis Spectrum Youths.

Authors:  David R Roalf; Megan Quarmley; Monica E Calkins; Theodore D Satterthwaite; Kosha Ruparel; Mark A Elliott; Tyler M Moore; Ruben C Gur; Raquel E Gur; Paul J Moberg; Bruce I Turetsky
Journal:  Schizophr Bull       Date:  2017-05-01       Impact factor: 9.306

2.  Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder.

Authors:  Stephanie M Y Wong; Y N Suen; Charlotte W C Wong; Sherry K W Chan; Christy L M Hui; W C Chang; Edwin H M Lee; Calvin P W Cheng; Garrett C L Ho; Gladys Goh Lo; Eric Y L Leung; Paul K M Au Yeung; Sirong Chen; William G Honer; Henry K F Mak; P C Sham; Peter J McKenna; Edith Pomarol-Clotet; Mattia Veronese; Oliver D Howes; Eric Y H Chen
Journal:  Psychopharmacology (Berl)       Date:  2022-02-25       Impact factor: 4.530

3.  Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study.

Authors:  Wing Chung Chang; Jasmine Tsz Ting Liu; Christy Lai Ming Hui; Sherry Kit Wa Chan; Edwin Ho Ming Lee; Yi Nam Suen; Eric Yu Hai Chen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2018-06-22       Impact factor: 5.270

Review 4.  Improving Knowledge on Pathways to Functional Outcome in Schizophrenia: Main Results From the Italian Network for Research on Psychoses.

Authors:  Luigi Giuliani; Giulia Maria Giordano; Paola Bucci; Pasquale Pezzella; Francesco Brando; Silvana Galderisi
Journal:  Front Psychiatry       Date:  2021-12-14       Impact factor: 4.157

5.  Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia.

Authors:  Nicholas R Livingston; Peter Ct Hawkins; James Gilleen; Rong Ye; Lorena Valdearenas; Sukhi S Shergill; Mitul A Mehta
Journal:  J Psychopharmacol       Date:  2021-04-28       Impact factor: 4.562

6.  Associations Between Negative Symptoms and Effort Discounting in Patients With Schizophrenia and Major Depressive Disorder.

Authors:  Flurin Cathomas; Federica Klaus; Karoline Guetter; Erich Seifritz; Matthias N Hartmann-Riemer; Philippe N Tobler; Stefan Kaiser; Mariia Kaliuzhna
Journal:  Schizophr Bull Open       Date:  2021-06-11

7.  Altered risky decision making in patients with early non-affective psychosis.

Authors:  Luk Msk; Chang Wc; Chong Csy; Siu Cmw; Chan Skw; Lee Emh; Hui Clm; Sun Yn; Lee Tmc; Lo Tl; Chen Eyh
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2019-02-26       Impact factor: 5.270

8.  Relationship of subjective quality of life with symptomatology, neurocognition and psychosocial functioning in first-episode psychosis: a structural equation modelling approach.

Authors:  Sandra Chi Yiu Wong; Wing Chung Chang; Christy Lai Ming Hui; Sherry Kit Wa Chan; Edwin Ho Ming Lee; Yi Nam Suen; Eric Yu Hai Chen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2021-07-25       Impact factor: 5.270

9.  Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis.

Authors:  Igne Sinkeviciute; Marieke Begemann; Merel Prikken; Bob Oranje; Erik Johnsen; Wan U Lei; Kenneth Hugdahl; Rune A Kroken; Carina Rau; Jolien D Jacobs; Silvia Mattaroccia; Iris E Sommer
Journal:  NPJ Schizophr       Date:  2018-10-25

10.  Targeting Cognition and Motivation in Coordinated Specialty Care for Early Psychosis: A Grant Report.

Authors:  Rachel Roisum; Danielle Jenkins; Melissa Fisher; Ariel Currie; Sisi Ma; Christopher Lindgren; Piper Meyer-Kalos; Sophia Vinogradov
Journal:  J Psychiatr Brain Sci       Date:  2020-10-16
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