Natalia Maldonado1, Bibiana Castro2, Indira Berrio3, Miguel Manjarrés4, Carlos Robledo5, Jaime Robledo6. 1. Laboratorio Médico de Referencia, Medellín, Colombia. Electronic address: investigaciones@labmedico.com. 2. Dirección de Gestión de Conocimiento, Universidad CES, Medellín, Colombia. 3. Clínica El Rosario Sede Centro, Medellín, Colombia. 4. Clínica El Rosario Sede Tesoro, Medellín, Colombia. 5. Laboratorio Médico de Referencia, Medellín, Colombia; Clínica El Rosario, Medellín, Colombia. 6. Laboratorio Médico de Referencia, Medellín, Colombia; Clínica El Rosario, Medellín, Colombia; Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas (CIB), Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia.
Abstract
INTRODUCTION: Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. METHODS: A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. RESULTS: The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). CONCLUSION: Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.
INTRODUCTION:Carbapenems resistance is a growing phenomenon and a threat to public health because of the reduced therapeutic options for resistant infections. METHODS: A retrospective case-control study was conducted in 2 tertiary-care hospitals in Medellín, Colombia. Fifty patients infected with ertapenem-resistant enterobacteriaceae were compared with a control group consisting of 100 patients with infections caused by ertapenem susceptible enterobacteriaceae. A multivariate logistic regression model was used to identify factors that best explain ertapenem-resistant enterobacteriaceae infections. RESULTS: The factors associated with ertapenem-resistant enterobacteriaceae infections were prior exposure to carbapenems (adjusted OR 3.43; 95% IC 1.08-10.87) and prior exposure to cefepime (adjusted OR 6.46; 95% IC 1.08-38.38). CONCLUSION: Prior exposure to antibiotics is the factor that best explains the ertapenem-resistant enterobacteriaceae infection in this population, highlighting the importance of antimicrobial stewardship programs in hospitals.