Megumi Hirokawa1, Masao Daimon2, Seitetsu L Lee1, Tomoko Nakao3, Takayuki Kawata1, Koichi Kimura1, Tomoko S Kato4, Yoshiko Mizuno5, Masafumi Watanabe1, Yutaka Yatomi3, Tsutomu Yamazaki6, Issei Komuro1. 1. Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan. 2. Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan. Electronic address: daimon@muf.biglobe.ne.jp. 3. Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan. 4. Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan; Department of Cardiovascular Surgery, Juntendo University School of Medicine, Tokyo, Japan. 5. Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan; Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan. 6. Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan.
Abstract
BACKGROUND: The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after their 50s and may contribute to the high prevalence of diastolic heart failure in elderly women. A decrease in estrogen levels after menopause is postulated to be one of the mechanisms responsible for this phenomenon. However, there is a paucity of data on the relationship between the timing of menopause and the progression of LVDD in the clinical setting; thus, we investigated this relationship in healthy postmenopausal women. METHODS: We enrolled 115 women and divided them into two groups according to median menopause age: 61 who experienced menopause at ≤50 years (early menopause group), and 54 who experienced menopause at >50 years (late menopause group). We compared the echocardiographic and clinical characteristics between the two groups. RESULTS: There were no significant differences in LV diastolic parameters (mitral E/A, p=0.561; e', p=0.052; E/e', p=0.081; DCT, p=0.082; prevalence of LVDD class, p=0.801), as well as other echocardiographic parameters and clinical characteristics between the two groups. Multivariate linear regression analysis showed that the independent determinants of LVDD were age and body mass index, but not the timing of menopause. CONCLUSIONS: Early menopause did not influence the progression of LVDD in postmenopausal women. The sharp progression of LVDD in elderly women is complex and probably influenced by multiple factors.
BACKGROUND: The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after their 50s and may contribute to the high prevalence of diastolic heart failure in elderly women. A decrease in estrogen levels after menopause is postulated to be one of the mechanisms responsible for this phenomenon. However, there is a paucity of data on the relationship between the timing of menopause and the progression of LVDD in the clinical setting; thus, we investigated this relationship in healthy postmenopausal women. METHODS: We enrolled 115 women and divided them into two groups according to median menopause age: 61 who experienced menopause at ≤50 years (early menopause group), and 54 who experienced menopause at >50 years (late menopause group). We compared the echocardiographic and clinical characteristics between the two groups. RESULTS: There were no significant differences in LV diastolic parameters (mitral E/A, p=0.561; e', p=0.052; E/e', p=0.081; DCT, p=0.082; prevalence of LVDD class, p=0.801), as well as other echocardiographic parameters and clinical characteristics between the two groups. Multivariate linear regression analysis showed that the independent determinants of LVDD were age and body mass index, but not the timing of menopause. CONCLUSIONS: Early menopause did not influence the progression of LVDD in postmenopausal women. The sharp progression of LVDD in elderly women is complex and probably influenced by multiple factors.
Authors: Jon Egelund; Peter G Jørgensen; Camilla M Mandrup; Thomas Fritz-Hansen; Bente Stallknecht; Jens Bangsbo; Michael Nyberg; Ylva Hellsten Journal: J Am Heart Assoc Date: 2017-08-18 Impact factor: 5.501