Antonello Veccia1, Orazio Caffo1, Ugo De Giorgi2, Giuseppe Di Lorenzo3, Cinzia Ortega4, Florinda Scognamiglio5, Michele Aieta6, Gaetano Facchini7, Giovanni Mansueto8, Rodolfo Mattioli9, Giuseppe Procopio10, Vittorina Zagonel11, Alessandro D'Angelo12, Gilbert Spizzo13, Roberto Bortolus14, Maddalena Donini15, Giovanni Lo Re16, Francesco Massari17, Giovanni Vicario18, Paolo A Zucali19, Daniele Alesini20, Andrea Bonetti21, Claudia Mucciarini22, Maurizio Nicodemo23, Alfredo Berruti24, Lucia Fratino25, Michele Lodde26, Caterina Messina27, Alessandra Perin28, Daniele Santini29, Teodoro Sava30, Marcello Tucci31, Umberto Basso11, Francesca Maines1, Luca S Burgio2, Enzo Galligioni1. 1. Medical Oncology Department, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy. 2. Medical Oncology Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, Italy. 3. Oncologia Urologica, Azienda Ospedaliera Universitaria "Federico II", Via S. Pansini 5, 80131 Napoli, Italy. 4. Medical Oncology Department, Institute for Cancer Research & Treatment, Strada Provinciale 142, Km 3.95, 10060 Candiolo, Italy. 5. Medical Oncology Department, Cardarelli Hospital, Via A. Cardarelli 9, 80131 Napoli, Italy. 6. Medical Oncology Department, Referral Cancer Center of Basilicata - IRCCS, Via Padre Pio, 1, 85028 Rionero in Vulture, Italy. 7. Division of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Via Mariano Semmola, 80131 Naples, Italy. 8. Medical Oncology Department, General Hospital, Via Fabi, 03100 Frosinone, Italy. 9. Medical Oncology Department, Santa Croce Hospital, Viale Vittorio Veneto 2, 61032 Fano, Italy. 10. Oncologia medica genitourinaria - Fondazione Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. 11. Medical Oncology Unit 1, Istituto Oncologico Veneto IOV - IRCCS, Via Gattamelata 64, 35128 Padua, Italy. 12. Medical Oncology Department, San Vincenzo Hospital, Via Sirina, 98039 Taormina, Italy. 13. Medical Oncology Department, General Hospital, Via Rossini, 5, 39012 Merano, Italy. 14. Radiation Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy. 15. Medical Oncology Department, Istituti Ospitalieri, Viale Concordia 1, 26100 Cremona, Italy. 16. Medical Oncology Department, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170 Pordenone, Italy. 17. Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale A. Scuro 10, 37134 Verona, Italy. 18. Medical Oncology Department, San Giacomo Apostolo Hospital, Via dei Carpani 16/Z, 31033 Castelfranco Veneto, Italy. 19. Department of Medical Oncology & Haematology, Humanitas Clinical & Research Center, Via Manzoni, 56, 20089 Rozzano, Italy. 20. Department of Radiological, Oncological & Anatomopathological Sciences, La Sapienza, University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. 21. Medical Oncology Department, Mater Salutis Hospital, Via Gianella, 1, 37045 Legnago, Italy. 22. Medical Oncology Department, Ramazzini Hospital, Via Guido Molinari, 2, 41012 Carpi, Italy. 23. Medical Oncology Department, Sacro Cuore Don Calabria Hospital, Via don A. Sempreboni, 5, 37024 Negrar, Italy. 24. Medical Oncology Department, Spedali Civili Hospital, P.le Spedali Civili, 1, 25123 Brescia, Italy. 25. Medical Oncology Department, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy. 26. Urology Department, General Hospital, Via Böhler 5, 39100 Bolzano, Italy. 27. Medical Oncology Department, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127 Bergamo, Italy. 28. Medical Oncology Department, General Hospital, via Garziere n. 42, 36014 Santorso, Italy. 29. Medical Oncology Department, University Campus Bio-Medico, Via Álvaro del Portillo, 00128 Rome, Italy. 30. Medical Oncology Department, General Hospital, P.le A. Stefani 1, 37126 Verona, Italy. 31. Medical Oncology Department, University of Torino, San Luigi Hospital, Regione Gonzole, 10, 10043 Orbassano, Italy.
Abstract
AIM: To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer. PATIENTS & METHODS: The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes. RESULTS: We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival. CONCLUSION: The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
AIM: To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer. PATIENTS & METHODS: The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes. RESULTS: We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival. CONCLUSION: The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.
Authors: Manuel Caitano Maia; Allan A Lima Pereira; Liana Valente Lage; Natalia Moreno Fraile; Victor Van Vaisberg; Guilherme Kudo; Romualdo Barroso-Sousa; Diogo Assed Bastos; Carlos Dzik Journal: J Glob Oncol Date: 2017-03-27