Ozan Yazıcı1, Nuriye Özdemir2, Ayşe Ocak Duran3, Serkan Menekşe4, Mehmet Ali Şendur2, Halit Karaca3, Gamze Göksel4, Erkan Arpacı5, İlhan Hacıbekiroğlu6, İrem Bilgetekin7, Turgut Kaçan8, Metin Özkan3, Sercan Aksoy1, Asude Aksoy9, Suna Çokmert10, Mükremin Uysal11, Emin Tamer Elkıran9, İrfan Çiçin6, Süleyman Büyükberber7, Nurullah Zengin1. 1. Ankara Numune Education & Research Hospital, Department of Medical Oncology, Sihhiye 06410, Ankara, Turkey. 2. Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Oncology, Bilkent Avenue 06800, Ankara, Turkey. 3. Erciyes University Faculty of Medicine, Department of Medical Oncology, Kayseri, Talas/Melikgazi 38030, Turkey. 4. Celal Bayar University Faculty of Medicine, Department of Medical Oncology, Uncubozköy 45030 Manisa, Turkey. 5. Sakarya University Education & Research Hospital, Department of Medical Oncology, Şirinevler 54100, Sakarya, Turkey. 6. Trakya University Faculty of Medicine, Department of Medical Oncology, Karaağaç 22050, Edirne, Turkey. 7. Gazi University Faculty of Medicine, Department of Medical Oncology, Emniyet 06560, Ankara, Turkey. 8. Cumhuriyet University Faculty of Medicine, Department of Medical Oncology, Sivas, Imaret 58140, Turkey. 9. İnönü University Faculty of Medicine, Department of Medical Oncology, Malatya, Centre 44000, Turkey. 10. Izmir Kent Hospital, Department of Medical Oncology, Izmir, Turkey. 11. Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
Abstract
AIM: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. PATIENTS & METHODS: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. RESULTS: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). CONCLUSION: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.
AIM: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancerpatients at the time of diagnosis. PATIENTS & METHODS: The survival rates of metastatic gastric cancerpatients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancerpatients whose primary tumor was nonresected. RESULTS: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). CONCLUSION: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.