Johan Anderzén1, Ulf Samuelsson2, Soffia Gudbjörnsdottir3, Lena Hanberger4, Karin Åkesson5. 1. Department of Paediatrics, Ryhov County Hospital, Jönköping Sweden. Electronic address: johan.anderzen@rjl.se. 2. Department of Clinical and Experimental Medicine, Division of Paediatrics and Diabetes. Research Centre, Linköping University Hospital, Linköping, Sweden. 3. Department of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 4. Department of Medical and Health Sciences, Division of Nursing, Linköping University, Linköping, Sweden. 5. Department of Paediatrics, Ryhov County Hospital, Jönköping Sweden; Futurum, Jönköping County Council and Jönköping Academy for improvement of health and welfare.
Abstract
AIMS: To evaluate how HbA1c in adolescents with type 1 diabetes affects microvascular complications in young adults. METHODS: All individuals registered in the Swedish paediatric diabetes quality registry (SWEDIABKIDS) 13-18 years of age, and as adults registered in the Swedish National Diabetes Registry (NDR) in both the years 2011 and 2012 were included, in total 4250 individuals. RESULTS: Of the individuals with mean HbA1c >78 mmol/mol in SWEDIABKIDS 83.4% had retinopathy, 15.8% had microalbuminuria and 4.9% had macroalbuminuria in NDR. The logistic regression analysis showed that the OR to develop macroalbuminuria as a young adult was significantly higher in the group with mean HbA1c >78 mmol/mol in SWEDIABKIDS (p<0.05). Among the patients with mean HbA1c above 78 mmol/mol in both registries there was a significantly higher proportion that had retinopathy, microalbuminuria (p<0.001) and/or macroalbuminuria (p<0.01) compared to the group with HbA1c below 57 mmol/mol in both registries. Only 6.5% of the persons in this study were over 30 years of age. CONCLUSIONS: Paediatric diabetes teams working with teenagers must be aware of the impact of good metabolic control during adolescence, and should intensify the care during this vulnerable period of life to reduce the risk of microvascular complications in young adults.
AIMS: To evaluate how HbA1c in adolescents with type 1 diabetes affects microvascular complications in young adults. METHODS: All individuals registered in the Swedish paediatric diabetes quality registry (SWEDIABKIDS) 13-18 years of age, and as adults registered in the Swedish National Diabetes Registry (NDR) in both the years 2011 and 2012 were included, in total 4250 individuals. RESULTS: Of the individuals with mean HbA1c >78 mmol/mol in SWEDIABKIDS 83.4% had retinopathy, 15.8% had microalbuminuria and 4.9% had macroalbuminuria in NDR. The logistic regression analysis showed that the OR to develop macroalbuminuria as a young adult was significantly higher in the group with mean HbA1c >78 mmol/mol in SWEDIABKIDS (p<0.05). Among the patients with mean HbA1c above 78 mmol/mol in both registries there was a significantly higher proportion that had retinopathy, microalbuminuria (p<0.001) and/or macroalbuminuria (p<0.01) compared to the group with HbA1c below 57 mmol/mol in both registries. Only 6.5% of the persons in this study were over 30 years of age. CONCLUSIONS: Paediatric diabetes teams working with teenagers must be aware of the impact of good metabolic control during adolescence, and should intensify the care during this vulnerable period of life to reduce the risk of microvascular complications in young adults.
Authors: Elizabeth Duarte Gómez; Gabriel Andrew Gregory; Miriam Castrati Nostas; Angela Christine Middlehurst; Alicia Josephine Jenkins; Graham David Ogle Journal: J Diabetes Res Date: 2017-08-29 Impact factor: 4.011
Authors: Ulrike Schierloh; Malgorzata E Wilinska; Ineke M Pit-Ten Cate; Petra Baumann; Roman Hovorka; Carine De Beaufort Journal: PLoS One Date: 2019-03-08 Impact factor: 3.240
Authors: Elisabet Nerpin; Eva Toft; Johan Fischier; Anna Lindholm-Olinder; Janeth Leksell Journal: BMC Endocr Disord Date: 2020-09-05 Impact factor: 2.763