| Literature DB >> 26775541 |
Meloddy H Manyeruke, Temitope O Olomola, Swarup Majumder, Shaakira Abrahams, Michelle Isaacs, Nicodemus Mautsa, Salerwe Mosebi, Dumisani Mnkandhla, Raymond Hewer, Heinrich C Hoppe, Rosalyn Klein, Perry T Kaye.
Abstract
Novel 3-hydroxy-3-phenylpropanoate ester-azidothymidine (AZT) conjugates have been prepared using Baylis-Hillman methodology, and their potential as dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors has been explored using enzyme inhibition and computer modelling techniques; their activity and HeLa cell toxicity have been compared with those of their cinnamate ester analogues.Entities:
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Year: 2015 PMID： 26775541 DOI： 10.1016/j.bmc.2015.10.039
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641