| Literature DB >> 26774932 |
Manuel Ehling1, Massimiliano Mazzone2.
Abstract
Targeting the aberrant, nonfunctional tumor vasculature is one of the most promising approaches of new anticancer therapies. Here, we discuss a recent publication and a novel mechanism by which tumor-associated macrophages can actively induce vessel normalization and junction stability, and improve the distribution of therapeutic drugs into a tumor.Entities:
Keywords: LIGHT; TGFβ; mural cell contractility; pericytes; tumor associated macrophages; tumor blood vessel normalization
Mesh：
Year: 2016 PMID： 26774932 DOI： 10.1016/j.molmed.2015.12.009
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951