Yuanyuan Liu1, Pu Lv1, Haiqiang Jin1, Wei Cui1, Chenguang Niu2, Mingming Zhao2, Chenghe Fan1, Yuming Teng1, Bing Pan2, Qing Peng1, Jingjing Luo1, Lemin Zheng3, Yining Huang4. 1. Department of Neurology, Peking University First Hospital, Beijing, China. 2. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China. 3. The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing, China. Electronic address: zhengl@bjmu.edu.cn. 4. Department of Neurology, Peking University First Hospital, Beijing, China. Electronic address: ynhuang@sina.com.
Abstract
BACKGROUND: Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. METHODS: Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. RESULTS: Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. CONCLUSIONS: This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.
BACKGROUND: Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. METHODS: Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. RESULTS: Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. CONCLUSIONS: This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs.
Authors: Ulf G Bronas; Alana Steffen; Catherine Dion; Elizabeth A Boots; Konstantinos Arfanakis; David X Marquez; Melissa Lamar Journal: Med Sci Sports Exerc Date: 2019-08 Impact factor: 5.411
Authors: Wen Bo Tian; Wei Sen Zhang; Chao Qiang Jiang; Xiang Yi Liu; Ya Li Jin; Tai Hing Lam; Kar Keung Cheng; Lin Xu Journal: Lancet Reg Health West Pac Date: 2022-05-03