Literature DB >> 26774863

T(reg) stability: to be or not to be.

Abigail E Overacre1, Dario Aa Vignali2.   

Abstract

Regulatory T cell (T(reg)) stability has been primarily determined by the maintained expression of the transcription factor Forkhead box P3 (Foxp3). However, T(regs) can exhibit instability while maintaining Foxp3 expression, requiring a re-examination of what defines T(reg) stability. Recent work suggests that the establishment and stability of T(regs) is mediated by a number of mechanisms besides Foxp3 expression, such as epigenetic modifications, Foxo1/3a localization, expression of Eos and signaling via Neuropilin-1. Additional studies may help to define approaches that can undermine T(reg) stability in cancer or enhance T(reg) stability in transplantation, autoimmune or inflammatory diseases and therefore have substantial therapeutic utility. In this review, we will discuss how T(reg) stability is defined and the mechanisms utilized to maintain stability.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26774863      PMCID： PMC4801724          DOI： 10.1016/j.coi.2015.12.009

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  40 in total

1.  Stability of the regulatory T cell lineage in vivo.

Authors:  Yuri P Rubtsov; Rachel E Niec; Steven Josefowicz; Li Li; Jaime Darce; Diane Mathis; Christophe Benoist; Alexander Y Rudensky
Journal:  Science       Date:  2010-09-24       Impact factor: 47.728

2.  Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

Authors:  Weiming Ouyang; Omar Beckett; Qian Ma; Ji-hye Paik; Ronald A DePinho; Ming O Li
Journal:  Nat Immunol       Date:  2010-05-13       Impact factor: 25.606

3.  Foxo transcription factors control regulatory T cell development and function.

Authors:  Yann M Kerdiles; Erica L Stone; Daniel R Beisner; Daniel L Beisner; Maureen A McGargill; Irene L Ch'en; Christian Stockmann; Carol D Katayama; Stephen M Hedrick
Journal:  Immunity       Date:  2010-12-14       Impact factor: 31.745

4.  PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors.

Authors:  Matthias Merkenschlager; Harald von Boehmer
Journal:  J Exp Med       Date:  2010-07-05       Impact factor: 14.307

Review 5.  Plasticity of CD4(+) FoxP3(+) T cells.

Authors:  Xuyu Zhou; Samantha Bailey-Bucktrout; Lukas T Jeker; Jeffrey A Bluestone
Journal:  Curr Opin Immunol       Date:  2009-06-06       Impact factor: 7.486

6.  CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

Authors:  Ashutosh Chaudhry; Dipayan Rudra; Piper Treuting; Robert M Samstein; Yuqiong Liang; Arnold Kas; Alexander Y Rudensky
Journal:  Science       Date:  2009-10-01       Impact factor: 47.728

7.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Authors:  Takahisa Miyao; Stefan Floess; Ruka Setoguchi; Hervé Luche; Hans Joerg Fehling; Herman Waldmann; Jochen Huehn; Shohei Hori
Journal:  Immunity       Date:  2012-02-09       Impact factor: 31.745

8.  Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.

Authors:  Robert M Samstein; Aaron Arvey; Steven Z Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Jeong M Kim; Will Liao; Ming O Li; Christina Leslie; John A Stamatoyannopoulos; Alexander Y Rudensky
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

9.  Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.

Authors:  Yohsuke Harada; Yasuyo Harada; Chris Elly; Ge Ying; Ji-Hye Paik; Ronald A DePinho; Yun-Cai Liu
Journal:  J Exp Med       Date:  2010-05-03       Impact factor: 14.307

10.  Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

Authors:  Xuyu Zhou; Samantha L Bailey-Bucktrout; Lukas T Jeker; Cristina Penaranda; Marc Martínez-Llordella; Meredith Ashby; Maki Nakayama; Wendy Rosenthal; Jeffrey A Bluestone
Journal:  Nat Immunol       Date:  2009-07-26       Impact factor: 25.606
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  38 in total

1.  Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells.

Authors:  E Ilker Ozay; Sudarvili Shanthalingam; Joe A Torres; Barbara A Osborne; Gregory N Tew; Lisa M Minter
Journal:  Mol Ther       Date:  2020-06-15       Impact factor: 11.454

Review 2.  Treg Fragility: A Prerequisite for Effective Antitumor Immunity?

Authors:  Abigail E Overacre-Delgoffe; Dario A A Vignali
Journal:  Cancer Immunol Res       Date:  2018-08       Impact factor: 11.151

Review 3.  Pathogenic CD4+ T cells in patients with asthma.

Authors:  Lyndsey M Muehling; Monica G Lawrence; Judith A Woodfolk
Journal:  J Allergy Clin Immunol       Date:  2017-04-22       Impact factor: 10.793

4.  NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.

Authors:  Zhenke Wen; Yasuhiro Shimojima; Tsuyoshi Shirai; Yinyin Li; Jihang Ju; Zhen Yang; Lu Tian; Jörg J Goronzy; Cornelia M Weyand
Journal:  J Clin Invest       Date:  2016-04-18       Impact factor: 14.808

Review 5.  Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

Authors:  Anabelle Visperas; Dario A A Vignali
Journal:  J Immunol       Date:  2016-11-15       Impact factor: 5.422

6.  Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.

Authors:  Abigail E Overacre-Delgoffe; Maria Chikina; Rebekah E Dadey; Hiroshi Yano; Erin A Brunazzi; Gulidanna Shayan; William Horne; Jessica M Moskovitz; Jay K Kolls; Cindy Sander; Yongli Shuai; Daniel P Normolle; John M Kirkwood; Robert L Ferris; Greg M Delgoffe; Tullia C Bruno; Creg J Workman; Dario A A Vignali
Journal:  Cell       Date:  2017-05-25       Impact factor: 41.582

7.  Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation.

Authors:  Catia S Verbeke; Susana Gordo; David A Schubert; Sarah A Lewin; Rajiv M Desai; Jessica Dobbins; Kai W Wucherpfennig; David J Mooney
Journal:  Adv Healthc Mater       Date:  2017-01-24       Impact factor: 9.933

Review 8.  Epigenetic mechanisms of tumor resistance to immunotherapy.

Authors:  Natalia Arenas-Ramirez; Dilara Sahin; Onur Boyman
Journal:  Cell Mol Life Sci       Date:  2018-08-23       Impact factor: 9.261

9.  Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation.

Authors:  James D Fisher; Stephen C Balmert; Wensheng Zhang; Riccardo Schweizer; Jonas T Schnider; Chiaki Komatsu; Liwei Dong; Vasil E Erbas; Jignesh V Unadkat; Ali Mübin Aral; Abhinav P Acharya; Yalcin Kulahci; Heth R Turnquist; Angus W Thomson; Mario G Solari; Vijay S Gorantla; Steven R Little
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-02       Impact factor: 11.205

10.  CD226 opposes TIGIT to disrupt Tregs in melanoma.

Authors:  Julien Fourcade; Zhaojun Sun; Joe-Marc Chauvin; Mignane Ka; Diwakar Davar; Ornella Pagliano; Hong Wang; Sofiane Saada; Carmine Menna; Rada Amin; Cindy Sander; John M Kirkwood; Alan J Korman; Hassane M Zarour
Journal:  JCI Insight       Date:  2018-07-26
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