Juan José Soler-Cataluña1, Jaume Sauleda2, Luis Valdés3, Pilar Marín4, Ramón Agüero5, Maite Pérez6, Marc Miravitlles7. 1. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Ciber de Enfermedades Respiratorias (CIBERES), Valencia, España. 2. Servicio de Neumología, Hospital Universitari Son Espases, Palma de Mallorca, España. 3. Servicio de Neumología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, La Coruña, España. 4. Servicio de Neumología, Hospital Universitario de Cruces, Barakaldo, Bizkaia, España. 5. Servicio de Neumología, Hospital Universitario Marqués de Valdecilla, Santander, España. 6. Departamento Médico, AstraZeneca Farmacéutica, Barcelona, España. 7. Servicio de Neumología, Hospital Universitari Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, España. Electronic address: mmiravitlles@vhebron.net.
Abstract
INTRODUCTION: Few studies have examined the 24-hour symptom profile in patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to determine daily variations in the symptoms of patients with stable COPD in Spain, compared with other European countries. METHODS: Observational study conducted in 8 European countries. The results from the Spanish cohort (n=122) are compared with the other European subjects (n=605). We included patients with COPD whose treatment had been unchanged in the previous 3months. Patients completed questionnaires on morning, day-time, and night-time symptoms of COPD, the COPD assessment test (CAT), the hospital anxiety and depression scale (HADS), and the COPD and asthma sleep impact scale (CASIS). RESULTS: Mean age: 69 (standard deviation [SD]=9) years; mean post-bronchodilator FEV1: 50.5 (SD=19.4)% (similar in Spanish and European cohorts). The proportion of men among the Spanish cohort was greater (91.0% versus 60.7%, P<.0001). A total of 52.5% patients experienced some type of symptom throughout the day, compared to 57.5% of the other Europeans, P<.001). Patients with symptoms throughout the day had poorer health-related quality of life (HRQoL) and higher levels of anxiety/depression than patients without symptoms. Patients with night-time symptoms had a poorer quality of sleep. Spanish patients with symptoms throughout the day had higher CAT scores (16.9 versus 20.5 in the other Europeans, P<.05). CONCLUSIONS: Despite receiving treatment, more than half of patients report symptoms throughout the day. These patients have poorer HRQoL and higher levels of anxiety/depression. Among patients with similar lung function, the Spanish cohort was less symptomatic and reported better HRQoL than other Europeans.
INTRODUCTION: Few studies have examined the 24-hour symptom profile in patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to determine daily variations in the symptoms of patients with stable COPD in Spain, compared with other European countries. METHODS: Observational study conducted in 8 European countries. The results from the Spanish cohort (n=122) are compared with the other European subjects (n=605). We included patients with COPD whose treatment had been unchanged in the previous 3months. Patients completed questionnaires on morning, day-time, and night-time symptoms of COPD, the COPD assessment test (CAT), the hospital anxiety and depression scale (HADS), and the COPD and asthma sleep impact scale (CASIS). RESULTS: Mean age: 69 (standard deviation [SD]=9) years; mean post-bronchodilator FEV1: 50.5 (SD=19.4)% (similar in Spanish and European cohorts). The proportion of men among the Spanish cohort was greater (91.0% versus 60.7%, P<.0001). A total of 52.5% patients experienced some type of symptom throughout the day, compared to 57.5% of the other Europeans, P<.001). Patients with symptoms throughout the day had poorer health-related quality of life (HRQoL) and higher levels of anxiety/depression than patients without symptoms. Patients with night-time symptoms had a poorer quality of sleep. Spanish patients with symptoms throughout the day had higher CAT scores (16.9 versus 20.5 in the other Europeans, P<.05). CONCLUSIONS: Despite receiving treatment, more than half of patients report symptoms throughout the day. These patients have poorer HRQoL and higher levels of anxiety/depression. Among patients with similar lung function, the Spanish cohort was less symptomatic and reported better HRQoL than other Europeans.
Keywords:
Calidad de vida relacionada con la salud; Chronic obstructive pulmonary disease; Enfermedad pulmonar obstructiva crónica; Health-related quality of life; Symptoms; Síntomas; Variabilidad; Variation
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