Hitoshi Mochizuki1, Akitoshi Taniguchi2, Yuki Nakazato3, Nobuyuki Ishii4, Yuka Ebihara5, Takashi Sugiyama6, Kazutaka Shiomi7, Masamitsu Nakazato8. 1. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: mochizuki-h@umin.net. 2. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: akitoshi_taniguchi@med.miyazaki-u.ac.jp. 3. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: yuuki_nakazato@med.miyazaki-u.ac.jp. 4. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: nobuyuki_ishii@med.miyazaki-u.ac.jp. 5. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: yuka_iwakiri@med.miyazaki-u.ac.jp. 6. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: t_sugiyama@med.miyazaki-u.ac.jp. 7. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: shiomik@med.miyazaki-u.ac.jp. 8. Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan. Electronic address: nakazato@med.miyazaki-u.ac.jp.
Abstract
BACKGROUND: The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD. METHODS: Clinical features, BMI, cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs. RESULTS: BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity. CONCLUSIONS: Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.
BACKGROUND: The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD. METHODS: Clinical features, BMI, cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs. RESULTS: BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity. CONCLUSIONS:Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PDpatients with high BMI.
Authors: Luís César de Medeiros; Marcella Campos Lima da Luz; Jarson Pedro da Costa Pereira; Gleyce Kelly Araújo Bezerra; Poliana Coelho Cabral Journal: Neurol Sci Date: 2021-10-22 Impact factor: 3.307
Authors: Maria S Pisciotta; Domenico Fusco; Giulia Grande; Vincenzo Brandi; Maria R Lo Monaco; Alice Laudisio; Graziano Onder; Anna R Bentivoglio; Diego Ricciardi; Roberto Bernabei; Giuseppe Zuccalà; Davide L Vetrano Journal: Aging Clin Exp Res Date: 2019-03-15 Impact factor: 3.636