| Literature DB >> 26774196 |
Aitor Esparza-Baquer1, Ibone Labiano1, Luis Bujanda2, María J Perugorria3, Jesús M Banales4.
Abstract
Cholangiopathies are the group of diseases targeting the bile duct epithelial cells (i.e. cholangiocytes). These disorders arise from different etiologies and represent a current diagnostic, prognostic and therapeutic challenge. Different molecular mechanisms participate in the development and progression of each type of biliary disease. However, microRNA deregulation is a common central event occurring in all of them that plays a key role in their pathogenesis. MicroRNAs are highly stable small non-coding RNAs present in cells, extracellular microvesicles and biofluids, representing valuable diagnostic tools and potential targets for therapy. In the following sections, the most novel and significant discoveries in this field are summarized and their potential clinical value is highlighted.Mesh：
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Year: 2016 PMID： 26774196 DOI： 10.1016/j.clinre.2015.10.001
Source DB: PubMed Journal: Clin Res Hepatol Gastroenterol ISSN： 2210-7401 Impact factor: 2.947