Hui Tao1, Jing-Jing Yang2, Kai-Hu Shi3, Jun Li4. 1. Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, China 230601; Cardiovascular Research Center, Anhui Medical University, Hefei, China 230601. 2. Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, China 230601. Electronic address: yjjncs01@126.com. 3. Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, China 230601; Cardiovascular Research Center, Anhui Medical University, Hefei, China 230601. Electronic address: ayskh3@hotmail.com. 4. School of pharmacy, Anhui Medical University, Hefei, China 230032.
Abstract
OBJECTIVE: Wnt signaling pathway significantly participates in cardiac fibrosis and CFs activation. Therefore, we reviewed current evidence on the new perspectives and biological association between Wnt signaling pathway and cardiac fibrosis. DESIGN AND METHODS: A PubMed database search was performed for studies of Wnt signaling pathway in cardiac fibrosis and CFs activation. RESULTS: Numerous studies have shown that the Wnt signaling pathway significantly participates in cardiac fibrosis pathogenesis. The aim of this review is to describe the present knowledge about the Wnt signaling pathway significantly participating in cardiac fibrosis and CFs activation, and look ahead on new perspectives of Wnt signaling pathway research. Moreover, we will discuss the different insights that interact with the Wnt signaling pathway-regulated cardiac fibrosis. The Wnt proteins are glycoproteins that bind to the Fz receptors on the cell surface, which lead to several important biological functions, such as cell differentiation and proliferation. There are several signals among the characterized pathways of cardiac fibrosis, including Wnt/β-catenin signaling. In this review, new insight into the Wnt signaling pathway in cardiac fibrosis pathogenesis is discussed, with special emphasis on Wnt/β-catenin. CONCLUSION: It seems reasonable to suggest the potential targets of Wnt signaling pathway and it can be developed as a therapeutic target for cardiac fibrosis.
OBJECTIVE: Wnt signaling pathway significantly participates in cardiac fibrosis and CFs activation. Therefore, we reviewed current evidence on the new perspectives and biological association between Wnt signaling pathway and cardiac fibrosis. DESIGN AND METHODS: A PubMed database search was performed for studies of Wnt signaling pathway in cardiac fibrosis and CFs activation. RESULTS: Numerous studies have shown that the Wnt signaling pathway significantly participates in cardiac fibrosis pathogenesis. The aim of this review is to describe the present knowledge about the Wnt signaling pathway significantly participating in cardiac fibrosis and CFs activation, and look ahead on new perspectives of Wnt signaling pathway research. Moreover, we will discuss the different insights that interact with the Wnt signaling pathway-regulated cardiac fibrosis. The Wnt proteins are glycoproteins that bind to the Fz receptors on the cell surface, which lead to several important biological functions, such as cell differentiation and proliferation. There are several signals among the characterized pathways of cardiac fibrosis, including Wnt/β-catenin signaling. In this review, new insight into the Wnt signaling pathway in cardiac fibrosis pathogenesis is discussed, with special emphasis on Wnt/β-catenin. CONCLUSION: It seems reasonable to suggest the potential targets of Wnt signaling pathway and it can be developed as a therapeutic target for cardiac fibrosis.
Authors: Aurelija Abraityte; Leif E Vinge; Erik T Askevold; Tove Lekva; Annika E Michelsen; Trine Ranheim; Katrine Alfsnes; Arnt Fiane; Svend Aakhus; Ida G Lunde; Christen P Dahl; Pål Aukrust; Geir Christensen; Lars Gullestad; Arne Yndestad; Thor Ueland Journal: J Mol Med (Berl) Date: 2017-03-30 Impact factor: 4.599