Literature DB >> 26773560

Establishing and maintaining cell polarity with mRNA localization in Drosophila.

Justinn Barr1, Konstantin V Yakovlev2,3, Yulii Shidlovskii2, Paul Schedl1,2.   

Abstract

How cell polarity is established and maintained is an important question in diverse biological contexts. Molecular mechanisms used to localize polarity proteins to distinct domains are likely context-dependent and provide a feedback loop in order to maintain polarity. One such mechanism is the localized translation of mRNAs encoding polarity proteins, which will be the focus of this review and may play a more important role in the establishment and maintenance of polarity than is currently known. Localized translation of mRNAs encoding polarity proteins can be used to establish polarity in response to an external signal, and to maintain polarity by local production of polarity determinants. The importance of this mechanism is illustrated by recent findings, including orb2-dependent localized translation of aPKC mRNA at the apical end of elongating spermatid tails in the Drosophila testis, and the apical localization of stardust A mRNA in Drosophila follicle and embryonic epithelia.
© 2016 WILEY Periodicals, Inc.

Entities:  

Keywords:  Par proteins; aPKC; mRNA localization; orb2; polarity; spermatogenesis; stardust

Mesh：

Substances：

Year:  2016        PMID： 26773560      PMCID： PMC4871591          DOI： 10.1002/bies.201500088

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  99 in total

1.  The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole.

Authors:  J M Shulman; R Benton; D St Johnston
Journal:  Cell       Date:  2000-05-12       Impact factor: 41.582

Review 2.  Elaborating polarity: PAR proteins and the cytoskeleton.

Authors:  Jeremy Nance; Jennifer A Zallen
Journal:  Development       Date:  2011-03       Impact factor: 6.868

3.  The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner.

Authors:  W Driever; C Nüsslein-Volhard
Journal:  Cell       Date:  1988-07-01       Impact factor: 41.582

4.  Polarization of both major body axes in Drosophila by gurken-torpedo signalling.

Authors:  A González-Reyes; H Elliott; D St Johnston
Journal:  Nature       Date:  1995-06-22       Impact factor: 49.962

5.  Bruno regulates gurken during Drosophila oogenesis.

Authors:  Paolo Filardo; Anne Ephrussi
Journal:  Mech Dev       Date:  2003-03       Impact factor: 1.882

6.  The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization.

Authors:  C Saunders; R S Cohen
Journal:  Mol Cell       Date:  1999-01       Impact factor: 17.970

7.  Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos.

Authors:  B Etemad-Moghadam; S Guo; K J Kemphues
Journal:  Cell       Date:  1995-12-01       Impact factor: 41.582

8.  orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.

Authors:  L B Christerson; D M McKearin
Journal:  Genes Dev       Date:  1994-03-01       Impact factor: 11.361

9.  Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein.

Authors:  Ulrich Hengst; Alessia Deglincerti; Hyung Joon Kim; Noo Li Jeon; Samie R Jaffrey
Journal:  Nat Cell Biol       Date:  2009-07-20       Impact factor: 28.824

10.  gurken and the I factor retrotransposon RNAs share common localization signals and machinery.

Authors:  Véronique Van De Bor; Eve Hartswood; Cheryl Jones; David Finnegan; Ilan Davis
Journal:  Dev Cell       Date:  2005-07       Impact factor: 12.270
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  7 in total

Review 1.  Regulation of Polarity Protein Levels in the Developing Central Nervous System.

Authors:  Christophe Laumonnerie; David J Solecki
Journal:  J Mol Biol       Date:  2018-06-01       Impact factor: 5.469

2.  Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila.

Authors:  Zaur M Kachaev; Lyubov A Lebedeva; Eugene N Kozlov; Ilya Y Toropygin; Paul Schedl; Yulii V Shidlovskii
Journal:  Cell Cycle       Date:  2018-08-01       Impact factor: 4.534

3.  The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.

Authors:  Rudolf Gilmutdinov; Eugene N Kozlov; Konstantin V Yakovlev; Ludmila V Olenina; Alexei A Kotov; Justinn Barr; Mariya Zhukova; Paul Schedl; Yulii V Shidlovskii
Journal:  Development       Date:  2021-09-09       Impact factor: 6.862

4.  The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.

Authors:  Rosa Pascual; Judit Martín; Fernando Salvador; Oscar Reina; Veronica Chanes; Alba Millanes-Romero; Clara Suñer; Gonzalo Fernández-Miranda; Anna Bartomeu; Yi-Shuian Huang; Roger R Gomis; Raúl Méndez
Journal:  Sci Adv       Date:  2020-05-15       Impact factor: 14.136

5.  Mapping parameter spaces of biological switches.

Authors:  Rocky Diegmiller; Lun Zhang; Marcio Gameiro; Justinn Barr; Jasmin Imran Alsous; Paul Schedl; Stanislav Y Shvartsman; Konstantin Mischaikow
Journal:  PLoS Comput Biol       Date:  2021-02-08       Impact factor: 4.475

Review 6.  The role of CPEB family proteins in the nervous system function in the norm and pathology.

Authors:  Eugene Kozlov; Yulii V Shidlovskii; Rudolf Gilmutdinov; Paul Schedl; Mariya Zhukova
Journal:  Cell Biosci       Date:  2021-03-31       Impact factor: 7.133

Review 7.  The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events.

Authors:  Shekoufeh Almasi; Bernard J Jasmin
Journal:  Cell Mol Life Sci       Date:  2021-10-11       Impact factor: 9.261
  7 in total

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