| Literature DB >> 26772918 |
Weiwei Zhang1, Rong Liu2, Chunhui Tang1, Qinghua Xi1, Shumin Lu3, Wenjuan Chen3, Lianxin Zhu4, Jialin Cheng3, Yannan Chen1, Wei Wang1, Jianxin Zhong5, Yan Deng6.
Abstract
PFTK1, also named Cyclin-Dependent Kinase 14 (CDK14), is a member of the cell division cycle 2 (CDC2)-related protein kinase family. It is a serine/threonine-protein kinase involved in the regulation of cell cycle progression and cell proliferation. In this study, we investigated the role of PFTK1 in epithelial ovarian cancer (EOC) development. The expression of PFTK1 was detected by Western blot and immunohistochemistry staining, both of which demonstrated that PFTK1 was overexpressed in EOC tissues and cells. Statistical analysis showed the expression of PFTK1 was associated with multiple clinicopathological factors, including tumor grade, FIGO stage, lymph node metastatis, Ki-67 expression and predicted a poor prognosis of EOC patients. With in vitro studies we found that PFTK1 expression was decreased in serum-starved ovarian cancer cells, and progressively increased after serum-re-feeding. Knocking PFTK1 down by small interfering RNA (siRNA) significantly inhibited ovarian cancer cell proliferation, migration and invasion. Taken together, our study suggested that PFTK1 played an important role in ovarian cancer development.Entities:
Keywords: Epithelial ovarian cancer; Overexpression; PFTK1
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Year: 2016 PMID： 26772918 DOI： 10.1016/j.ijbiomac.2016.01.009
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953