Literature DB >> 26772627

Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway.

Kangxiang Ji1, Long Xue2, Jiwei Cheng1, Yu Bai3.   

Abstract

It is of great importance to protect the brain against cerebral ischemia and reperfusion (I/R) injury, which leads to excitotoxicity, redox imbalance, inflammation and apoptosis; however, there is currently no effective treatment. The present study aimed to investigate the effect of H2S preconditioning on cerebral I/R injury and its underlying mechanism. The results demonstrated that H2S preconditioning significantly prevented the development of neurological function abnormality, inflammation and oxidative injury in mice as well as cognitive impairment caused by cerebral I/R. H2S preconditioning also suppressed the apoptosis caused by cerebral I/R. Moreover, the protective effect of H2S preconditioning was found to involve heat shock protein 70 (HSP70), in which the PI3K/Akt/Nrf2 pathway was involved. The data showed that H2S preconditioning could protect mice against cerebral I/R injury by the induction of HSP70 and the PI3K/Akt/Nrf2 pathway.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Akt; H(2)S; HSP70; Ischemia-reperfusion; Nrf2; PI3K

Mesh：

Substances：

Year:  2016        PMID： 26772627     DOI： 10.1016/j.brainresbull.2015.12.007

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  21 in total

1.  Hydrogen sulfide alleviates cigarette smoke-induced COPD through inhibition of the TGF-β1/smad pathway.

Authors:  Liang Wang; Jing Meng; Caicai Wang; Chao Yang; Yuan Wang; Yamei Li; Yujing Li
Journal:  Exp Biol Med (Maywood)       Date:  2020-02-02

2.  Effect of magnolol on cerebral injury and blood brain barrier dysfunction induced by ischemia-reperfusion in vivo and in vitro.

Authors:  Xiaoyan Liu; Xiaoling Chen; Yuanjun Zhu; Kewei Wang; Yinye Wang
Journal:  Metab Brain Dis       Date:  2017-04-04       Impact factor: 3.584

3.  O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice.

Authors:  Jingru Zhao; Lipeng Dong; Tiantian Huo; Jinming Cheng; Xiaojuan Li; Xiaojuan Huangfu; Sujuan Sun; Hebo Wang; Litao Li
Journal:  Neuromolecular Med       Date:  2021-10-27       Impact factor: 4.103

Review 4.  International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors.

Authors:  Csaba Szabo; Andreas Papapetropoulos
Journal:  Pharmacol Rev       Date:  2017-10       Impact factor: 25.468

Review 5.  Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Authors:  Manuel Matzinger; Katrin Fischhuber; Elke H Heiss
Journal:  Biotechnol Adv       Date:  2017-12-28       Impact factor: 14.227

6.  L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism.

Authors:  Tingting Li; Jiangbing Li; Tong Li; Yijing Zhao; Hongfei Ke; Shuanglian Wang; Dexiang Liu; Zhen Wang
Journal:  Drug Des Devel Ther       Date:  2021-02-11       Impact factor: 4.162

Review 7.  Protective Effect of Hydrogen Sulfide on Cerebral Ischemia-Reperfusion Injury.

Authors:  Masood Muqadas; Salah Adlat; Gang Deng; Haiyun Zheng; Ge Li; Ping Zhu; M I Nasser
Journal:  Cell Mol Neurobiol       Date:  2022-01-23       Impact factor: 5.046

8.  Pre- and posttreatment with hydrogen sulfide prevents ventilator-induced lung injury by limiting inflammation and oxidation.

Authors:  Simone Faller; Raphael Seiler; Rosa Donus; Helen Engelstaedter; Alexander Hoetzel; Sashko Gregoriev Spassov
Journal:  PLoS One       Date:  2017-04-28       Impact factor: 3.240

9.  The Effect of Dexmedetomidine on Oxidative Stress Response Following Cerebral Ischemia-Reperfusion in Rats and the Expression of Intracellular Adhesion Molecule-1 (ICAM-1) and S100B.

Authors:  Yanwen Li; Shikun Liu
Journal:  Med Sci Monit       Date:  2017-02-17

10.  The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation.

Authors:  Da Zhang; Xiuli Wang; Xiaoyu Tian; Lulu Zhang; Guosheng Yang; Yinghong Tao; Chen Liang; Kun Li; Xiaoqi Yu; Xinjing Tang; Chaoshu Tang; Jing Zhou; Wei Kong; Junbao Du; Yaqian Huang; Hongfang Jin
Journal:  Front Immunol       Date:  2018-04-30       Impact factor: 7.561
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