OBJECTS: To examine how vascular endothelia (VE)-cadherin plasma levels are correlated with parameters associated with endothelial function such as endothelin-1, nitric oxide, nitric oxide synthase and HbA1c in type 2 diabetic patients with coronary artery disease. METHODS: VE-cadherin levels were analyzed by enzyme-linked immunosorbent assays. Spearman's correlation and multiple stepwise regression analyses were used to examine the relationship between plasma VE-cadherin and other factors. RESULTS: By univariate correlation analysis, plasma VE-cadherin levels were significantly associated with age, total cholesterol, triglyceride, hemoglobin A1c, and endothelin-1. Multiple regression analysis (adjusted for age, total cholesterol, and triglyceride) showed that plasma VE-cadherin levels were independently and significantly associated with HbA1c and ET-1. Plasma VE-cadherin levels were significantly highest in patients with diabetes mellitus and coronary artery disease. While patients with diabetes mellitus had higher levels of VE-cadherin compared with healthy subjects. CONCLUSIONS: This study found that VE-cadherin levels might be a biomarker for some endothelial dysfunction associated with coronary artery disease in type 2 diabetes mellitus.
OBJECTS: To examine how vascular endothelia (VE)-cadherin plasma levels are correlated with parameters associated with endothelial function such as endothelin-1, nitric oxide, nitric oxide synthase and HbA1c in type 2 diabeticpatients with coronary artery disease. METHODS:VE-cadherin levels were analyzed by enzyme-linked immunosorbent assays. Spearman's correlation and multiple stepwise regression analyses were used to examine the relationship between plasma VE-cadherin and other factors. RESULTS: By univariate correlation analysis, plasma VE-cadherin levels were significantly associated with age, total cholesterol, triglyceride, hemoglobin A1c, and endothelin-1. Multiple regression analysis (adjusted for age, total cholesterol, and triglyceride) showed that plasma VE-cadherin levels were independently and significantly associated with HbA1c and ET-1. Plasma VE-cadherin levels were significantly highest in patients with diabetes mellitus and coronary artery disease. While patients with diabetes mellitus had higher levels of VE-cadherin compared with healthy subjects. CONCLUSIONS: This study found that VE-cadherin levels might be a biomarker for some endothelial dysfunction associated with coronary artery disease in type 2 diabetes mellitus.
Entities:
Keywords:
Vascular endothelia-cadherin; coronary artery disease; type 2 diabetes mellitus
Authors: Peter J Kuhlencordt; Stefanie Hötten; Johannes Schödel; Sebastian Rützel; Kai Hu; Julian Widder; Alexander Marx; Paul L Huang; Georg Ertl Journal: Arterioscler Thromb Vasc Biol Date: 2006-04-20 Impact factor: 8.311
Authors: Andrzej Surdacki; Olga Kruszelnicka; Tomasz Rakowski; Aleksandra Jaźwińska-Kozuba; Jacek S Dubiel Journal: Cardiovasc Diabetol Date: 2013 Impact factor: 9.951
Authors: Lars Brodowski; Bianca Schröder-Heurich; Berina Kipke; Cara Schmidt; Constantin S von Kaisenberg; Frauke von Versen-Höynck Journal: Cardiovasc Ther Date: 2020-09-22 Impact factor: 3.023
Authors: Ka Ka Ting; Yang Zhao; Weiyong Shen; Paul Coleman; Michelle Yam; Tailoi Chan-Ling; Jia Li; Thorleif Moller; Mark Gillies; Mathew A Vadas; Jennifer R Gamble Journal: Diabetologia Date: 2018-11-15 Impact factor: 10.122
Authors: Rayana A P Maciel; Regiane S Cunha; Valentina Busato; Célia R C Franco; Paulo C Gregório; Carla J R Dolenga; Lia S Nakao; Ziad A Massy; Agnès Boullier; Roberto Pecoits-Filho; Andréa E M Stinghen Journal: Toxins (Basel) Date: 2018-10-07 Impact factor: 4.546