Literature DB >> 26769490

The Orphan Nuclear Receptor TLX/NR2E1 in Neural Stem Cells and Diseases.

Tao Wang1, Jian-Qiong Xiong2.   

Abstract

The human TLX gene encodes an orphan nuclear receptor predominantly expressed in the central nervous system. Tailess and Tlx, the TLX homologues in Drosophila and mouse, play essential roles in body-pattern formation and neurogenesis during early embryogenesis and perform crucial functions in maintaining stemness and controlling the differentiation of adult neural stem cells in the central nervous system, especially the visual system. Multiple target genes and signaling pathways are regulated by TLX and its homologues in specific tissues during various developmental stages. This review aims to summarize previous studies including many recent updates from different aspects concerning TLX and its homologues in Drosophila and mouse.

Entities:  

Keywords:  Neural stem cell; Neurogenesis; TLX

Mesh：

Substances：

Year:  2016        PMID： 26769490      PMCID： PMC5563749          DOI： 10.1007/s12264-015-0004-7

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  74 in total

1.  Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics.

Authors:  Piergiorgio Modena; Elena Lualdi; Federica Facchinetti; Joris Veltman; James F Reid; Simone Minardi; Irene Janssen; Felice Giangaspero; Marco Forni; Gaetano Finocchiaro; Lorenzo Genitori; Flavio Giordano; Riccardo Riccardi; Eric F P M Schoenmakers; Maura Massimino; Gabriella Sozzi
Journal:  J Clin Oncol       Date:  2006-11-20       Impact factor: 44.544

2.  Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.

Authors:  Brett S Abrahams; Melvin C H Kwok; Eric Trinh; Saeed Budaghzadeh; Sazzad M Hossain; Elizabeth M Simpson
Journal:  J Neurosci       Date:  2005-07-06       Impact factor: 6.167

3.  Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development.

Authors:  B Hartmann; H Reichert; U Walldorf
Journal:  Mech Dev       Date:  2001-12       Impact factor: 1.882

4.  Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.

Authors:  J-F Schmouth; K G Banks; A Mathelier; C Y Gregory-Evans; M Castellarin; R A Holt; K Gregory-Evans; W W Wasserman; E M Simpson
Journal:  Mol Cell Biol       Date:  2012-01-30       Impact factor: 4.272

5.  The zebrafish orphan nuclear receptor genes nr2e1 and nr2e3 are expressed in developing eye and forebrain.

Authors:  Satish Srinivas Kitambi; Giselbert Hauptmann
Journal:  Gene Expr Patterns       Date:  2006-10-21       Impact factor: 1.224

6.  Complex regulatory region mediating tailless expression in early embryonic patterning and brain development.

Authors:  K M Rudolph; G J Liaw; A Daniel; P Green; A J Courey; V Hartenstein; J A Lengyel
Journal:  Development       Date:  1997-11       Impact factor: 6.868

7.  The Tlx gene regulates the timing of neurogenesis in the cortex.

Authors:  Kristine Roy; Kathleen Kuznicki; Qiang Wu; Zhuoxin Sun; Dagmar Bock; Gunther Schutz; Nancy Vranich; A Paula Monaghan
Journal:  J Neurosci       Date:  2004-09-22       Impact factor: 6.167

8.  The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.

Authors:  Bruno Bello; Heinrich Reichert; Frank Hirth
Journal:  Development       Date:  2006-06-14       Impact factor: 6.868

9.  Structural basis for corepressor assembly by the orphan nuclear receptor TLX.

Authors:  Xiaoyong Zhi; X Edward Zhou; Yuanzheng He; Kelvin Searose-Xu; Chun-Li Zhang; Chih-Cheng Tsai; Karsten Melcher; H Eric Xu
Journal:  Genes Dev       Date:  2015-02-15       Impact factor: 11.361

10.  Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.

Authors:  Qiuhao Qu; Guoqiang Sun; Wenwu Li; Su Yang; Peng Ye; Chunnian Zhao; Ruth T Yu; Fred H Gage; Ronald M Evans; Yanhong Shi
Journal:  Nat Cell Biol       Date:  2009-12-13       Impact factor: 28.824
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  6 in total

Review 1.  Nuclear receptors in neural stem/progenitor cell homeostasis.

Authors:  Dimitrios Gkikas; Matina Tsampoula; Panagiotis K Politis
Journal:  Cell Mol Life Sci       Date:  2017-06-21       Impact factor: 9.261

Review 2.  TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease.

Authors:  Adam T Nelson; Yu Wang; Erik R Nelson
Journal:  Endocrinology       Date:  2021-11-01       Impact factor: 5.051

3.  FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.

Authors:  Luca Braccioli; Stephin J Vervoort; Youri Adolfs; Cobi J Heijnen; Onur Basak; R Jeroen Pasterkamp; Cora H Nijboer; Paul J Coffer
Journal:  Stem Cell Reports       Date:  2017-11-14       Impact factor: 7.765

Review 4.  Key Role of Astrocytes in Postnatal Brain and Retinal Angiogenesis.

Authors:  Mariela Puebla; Pablo J Tapia; Hilda Espinoza
Journal:  Int J Mol Sci       Date:  2022-02-28       Impact factor: 5.923

5.  Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles.

Authors:  Mingzhi Xu; Gang Chen; Yanan Dong; Shensi Xiang; Miaomiao Xue; Yongxue Liu; Haijing Song; Haifeng Song; Yi Wang
Journal:  Stem Cell Res Ther       Date:  2022-09-02       Impact factor: 8.079

6.  Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.

Authors:  Lin Jia; Dinglan Wu; Yuliang Wang; Wenxing You; Zhu Wang; Lijia Xiao; Ganhui Cai; Zhenyu Xu; Chang Zou; Fei Wang; Jeremy Yuen-Chun Teoh; Chi-Fai Ng; Shan Yu; Franky L Chan
Journal:  Oncogene       Date:  2018-03-20       Impact factor: 9.867
  6 in total

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