| Literature DB >> 26769396 |
Hai Xuan Nguyen1, Nhan Trung Nguyen1, Phu Hoang Dang1, Phuoc Thi Ho1, Mai Thanh Thi Nguyen2, Mao Van Can3, Dya Fita Dibwe4, Jun-Ya Ueda4, Suresh Awale5.
Abstract
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.Entities:
Keywords: Antiausterity agent; Caesalpinia sappan; Caesalpiniaceae; Cassane diterpene; PANC-1
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Year: 2016 PMID： 26769396 DOI： 10.1016/j.phytochem.2015.12.018
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072