Literature DB >> 26768769

Anti-cancer effects of vitamin C revisited.

Jiska van der Reest1, Eyal Gottlieb1.   

Abstract

Vitamin C was first suggested to have cancer-fighting properties in the 1930s and has been the subject of controversy ever since. Despite repeated reports of selective cancer cell toxicity induced by high-dose vitamin C treatment in vitro and in mouse models, the mechanism of action has remained elusive.

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Year:  2016        PMID: 26768769      PMCID: PMC4783474          DOI: 10.1038/cr.2016.7

Source DB:  PubMed          Journal:  Cell Res        ISSN: 1001-0602            Impact factor:   25.617


  10 in total

1.  Ascorbic acid supplements and kidney stone incidence among men: a prospective study.

Authors:  Laura D K Thomas; Carl-Gustaf Elinder; Hans-Göran Tiselius; Alicja Wolk; Agneta Akesson
Journal:  JAMA Intern Med       Date:  2013-03-11       Impact factor: 21.873

2.  Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells.

Authors:  C Spielholz; D W Golde; A N Houghton; F Nualart; J C Vera
Journal:  Cancer Res       Date:  1997-06-15       Impact factor: 12.701

3.  Stromal cell oxidation: a mechanism by which tumors obtain vitamin C.

Authors:  D B Agus; J C Vera; D W Golde
Journal:  Cancer Res       Date:  1999-09-15       Impact factor: 12.701

4.  Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.

Authors:  D B Agus; S S Gambhir; W M Pardridge; C Spielholz; J Baselga; J C Vera; D W Golde
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

Review 5.  Ascorbate function and metabolism in the human erythrocyte.

Authors:  J M May
Journal:  Front Biosci       Date:  1998-01-01

Review 6.  Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review.

Authors:  Carmel Jacobs; Brian Hutton; Terry Ng; Risa Shorr; Mark Clemons
Journal:  Oncologist       Date:  2015-01-19

Review 7.  Targeting the DNA Damage Response in Cancer.

Authors:  Mark J O'Connor
Journal:  Mol Cell       Date:  2015-11-19       Impact factor: 17.970

8.  Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid.

Authors:  J C Vera; C I Rivas; J Fischbarg; D W Golde
Journal:  Nature       Date:  1993-07-01       Impact factor: 49.962

9.  Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.

Authors:  Jihye Yun; Edouard Mullarky; Changyuan Lu; Kaitlyn N Bosch; Adam Kavalier; Keith Rivera; Jatin Roper; Iok In Christine Chio; Eugenia G Giannopoulou; Carlo Rago; Ashlesha Muley; John M Asara; Jihye Paik; Olivier Elemento; Zhengming Chen; Darryl J Pappin; Lukas E Dow; Nickolas Papadopoulos; Steven S Gross; Lewis C Cantley
Journal:  Science       Date:  2015-11-05       Impact factor: 47.728

10.  Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

Authors:  Sarah E Bohndiek; Mikko I Kettunen; De-en Hu; Brett W C Kennedy; Joan Boren; Ferdia A Gallagher; Kevin M Brindle
Journal:  J Am Chem Soc       Date:  2011-07-08       Impact factor: 15.419

  10 in total
  17 in total

1.  Effects of vitamin C on osteoblast proliferation and osteosarcoma inhibition using plasma coated hydroxyapatite on titanium implants.

Authors:  Naboneeta Sarkar; Hailey Morton; Susmita Bose
Journal:  Surf Coat Technol       Date:  2020-04-15       Impact factor: 4.158

Review 2.  A guide to plasma membrane solute carrier proteins.

Authors:  Mattia D Pizzagalli; Ariel Bensimon; Giulio Superti-Furga
Journal:  FEBS J       Date:  2020-09-18       Impact factor: 5.542

3.  Citric Juice-mediated Synthesis of Tellurium Nanoparticles with Antimicrobial and Anticancer Properties.

Authors:  David Medina Cruz; William Tien-Street; Bohan Zhang; Xinjing Huang; Ada Vernet Crua; Alfonso Nieto-Argüello; Jorge L Cholula-Díaz; Lidia Martínez; Yves Huttel; María Ujué González; José Miguel García-Martín; Thomas J Webster
Journal:  Green Chem       Date:  2019-03-11       Impact factor: 10.182

Review 4.  The Role of Nutritional Support in Malnourished Patients With Lung Cancer.

Authors:  Agata Kasprzyk; Krzysztof Bilmin; Tomira Chmielewska-Ignatowicz; Jakub Pawlikowski; Urszula Religioni; Piotr Merks
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.406

5.  High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells.

Authors:  Maria Leticia Castro; Georgia M Carson; Melanie J McConnell; Patries M Herst
Journal:  Antioxidants (Basel)       Date:  2017-07-22

6.  Vitamin C Loaded Polyethylene: Synthesis and Properties of Precise Polyethylene with Vitamin C Defects via Acyclic Diene Metathesis Polycondensation.

Authors:  Oksana Suraeva; Carole Champanhac; Volker Mailänder; Frederik R Wurm; Henning Weiss; Rüdiger Berger; Markus Mezger; Katharina Landfester; Ingo Lieberwirth
Journal:  Macromolecules       Date:  2020-04-08       Impact factor: 5.985

7.  Vitamin C Inhibits Metastasis of Peritoneal Tumors By Preventing Spheroid Formation in ID8 Murine Epithelial Peritoneal Cancer Model.

Authors:  Yayun Xu; Xing Guo; Ganyu Wang; Changkuo Zhou
Journal:  Front Pharmacol       Date:  2020-05-12       Impact factor: 5.810

Review 8.  Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics.

Authors:  Cristina D'Aniello; Federica Cermola; Eduardo Jorge Patriarca; Gabriella Minchiotti
Journal:  Stem Cells Int       Date:  2017-04-20       Impact factor: 5.443

Review 9.  Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.

Authors:  Gina Nauman; Javaughn Corey Gray; Rose Parkinson; Mark Levine; Channing J Paller
Journal:  Antioxidants (Basel)       Date:  2018-07-12

10.  Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations.

Authors:  Bhimashankar Gurushidhappa Utage; Milind Shivajirao Patole; Punam Vasudeo Nagvenkar; Sonali Shankar Kamble; Rajesh Nivarti Gacche
Journal:  Oncotarget       Date:  2018-07-13
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