| Literature DB >> 26768612 |
Zhongguo Zhou1, Rongxin Zhang1, Ruojing Wang2, Yaojun Zhang1, Li Xu1, Jinbin Chen1, Jie Zhang1, Zhongxi Huang1, Minshan Chen3, Zhizhong Pan4.
Abstract
There is increasing evidence suggesting that the establishment of Pim-3 is involved in tumorigenesis. This study aimed to investigate the expression and clinicopathological significance of Pim-3 in colorectal cancer (CRC). Clinical pathology data were collected from 410 CRC patients who received radical resection and were pathologically confirmed at the Sun Yat-Sen University Cancer Center between October 2002 and December 2008. We compared the expression Pim-3 in the primary focus and liver metastasis and investigated the correlations with other clinical-pathological factors. Multivariate analysis showed that perioperative blood transfusion, local invasion, lymph node and liver metastasis, and Pim-3 expression were independent prognostic factors. The expression of Pim-3 in CRC was higher than that in normal tissues. Patients with positive expression had significant decreases in 5-year survival. Pim-3 expression showed a positive correlation with tumor cell differentiation, local infiltration, and lymph node and liver metastasis. In conclusion, Pim-3 might serve as a novel target and prognosis factor for colorectal cancer.Entities:
Keywords: Colorectal cancer; Metastasis; Pim-3; Prognosis
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Year: 2016 PMID： 26768612 DOI： 10.1007/s13277-016-4806-7
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283