Literature DB >> 26768304

Structure elucidation of uniformly (13)C labeled small molecule natural products.

Mikhail Reibarkh1, Thomas P Wyche2, Josep Saurí1, Tim S Bugni2, Gary E Martin1, R Thomas Williamson1.   

Abstract

Utilization of (2)H, (13)C, and (15)N isotopically labeled proteins and peptides is now routine in biomolecular NMR investigations. The widespread availability of inexpensive, uniformly (13) C enriched glucose now makes it possible to isolate uniformly (13)C labeled natural products from microbial fermentation. We now wish to describe an approach for the rapid structural characterization of uniformly (13)C labeled natural products that avoids the pitfalls of relying on parameters typically employed in biomolecular NMR studies.
Copyright © 2015 John Wiley & Sons, Ltd.

Entities:  

Keywords:  13C-13C COSY and COSYLR; CT-HSQC; U-13C labeled; enterocin; natural products; structure elucidation

Mesh：

Substances：

Year:  2015        PMID： 26768304     DOI： 10.1002/mrc.4333

Source DB:  PubMed          Journal:  Magn Reson Chem        ISSN： 0749-1581            Impact factor:   2.447


  3 in total

1.  Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.

Authors:  Thomas P Wyche; René F Ramos Alvarenga; Jeff S Piotrowski; Megan N Duster; Simone R Warrack; Gabriel Cornilescu; Travis J De Wolfe; Yanpeng Hou; Doug R Braun; Gregory A Ellis; Scott W Simpkins; Justin Nelson; Chad L Myers; James Steele; Hirotada Mori; Nasia Safdar; John L Markley; Scott R Rajski; Tim S Bugni
Journal:  ACS Chem Biol       Date:  2017-07-26       Impact factor: 5.100

Review 2.  The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

Authors:  James B McAlpine; Shao-Nong Chen; Andrei Kutateladze; John B MacMillan; Giovanni Appendino; Andersson Barison; Mehdi A Beniddir; Maique W Biavatti; Stefan Bluml; Asmaa Boufridi; Mark S Butler; Robert J Capon; Young H Choi; David Coppage; Phillip Crews; Michael T Crimmins; Marie Csete; Pradeep Dewapriya; Joseph M Egan; Mary J Garson; Grégory Genta-Jouve; William H Gerwick; Harald Gross; Mary Kay Harper; Precilia Hermanto; James M Hook; Luke Hunter; Damien Jeannerat; Nai-Yun Ji; Tyler A Johnson; David G I Kingston; Hiroyuki Koshino; Hsiau-Wei Lee; Guy Lewin; Jie Li; Roger G Linington; Miaomiao Liu; Kerry L McPhail; Tadeusz F Molinski; Bradley S Moore; Joo-Won Nam; Ram P Neupane; Matthias Niemitz; Jean-Marc Nuzillard; Nicholas H Oberlies; Fernanda M M Ocampos; Guohui Pan; Ronald J Quinn; D Sai Reddy; Jean-Hugues Renault; José Rivera-Chávez; Wolfgang Robien; Carla M Saunders; Thomas J Schmidt; Christoph Seger; Ben Shen; Christoph Steinbeck; Hermann Stuppner; Sonja Sturm; Orazio Taglialatela-Scafati; Dean J Tantillo; Robert Verpoorte; Bin-Gui Wang; Craig M Williams; Philip G Williams; Julien Wist; Jian-Min Yue; Chen Zhang; Zhengren Xu; Charlotte Simmler; David C Lankin; Jonathan Bisson; Guido F Pauli
Journal:  Nat Prod Rep       Date:  2018-07-13       Impact factor: 13.423

3.  Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.

Authors:  Thomas P Wyche; Antonio C Ruzzini; Laura Schwab; Cameron R Currie; Jon Clardy
Journal:  J Am Chem Soc       Date:  2017-09-06       Impact factor: 15.419
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.