Literature DB >> 26767647

Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma.

Amir Mehdizadeh1,2, Mohammad Hossein Somi1, Masoud Darabi2, Mortaza Jabbarpour-Bonyadi3,4.   

Abstract

Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

Entities:  

Keywords:  Chemoresistance; ERK; Hepatocellular carcinoma

Mesh：

Substances：

Year:  2016        PMID： 26767647     DOI： 10.1007/s11033-016-3943-9

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  72 in total

Review 1.  Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.

Authors:  Lionel Larue; Alfonso Bellacosa
Journal:  Oncogene       Date:  2005-11-14       Impact factor: 9.867

Review 2.  Cancer chemoresistance: the relationship between p53 and multidrug transporters.

Authors:  Jason A Bush; Gang Li
Journal:  Int J Cancer       Date:  2002-03-20       Impact factor: 7.396

3.  The ERK Cascade: Distinct Functions within Various Subcellular Organelles.

Authors:  Inbal Wortzel; Rony Seger
Journal:  Genes Cancer       Date:  2011-03

4.  The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.

Authors:  Patrick J Klein; C Max Schmidt; Chad A Wiesenauer; Jennifer N Choi; Earl A Gage; Michele T Yip-Schneider; Eric A Wiebke; Yufang Wang; Charles Omer; Judith S Sebolt-Leopold
Journal:  Neoplasia       Date:  2006-01       Impact factor: 5.715

5.  Inhibition of MEK/ERK1/2 Signaling Affects the Fatty Acid Composition of HepG2 Human Hepatic Cell Line.

Authors:  Bahman Yousefi; Masoud Darabi; Behzad Baradaran; Mahmoud Shekari Khaniani; Mohammad Rahbani; Maryam Darabi; Shabnam Fayezi; Amir Mehdizadeh; Negar Saliani; Maghsod Shaaker
Journal:  Bioimpacts       Date:  2012-06-27

6.  PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway.

Authors:  Negar Saliani; Masoud Darabi; Bahman Yousefi; Behzad Baradaran; Mahmoud Shekari Khaniani; Maryam Darabi; Maghsod Shaaker; Amir Mehdizadeh; Tahereh Naji; Mehrdad Hashemi
Journal:  World J Hepatol       Date:  2013-04-27

7.  MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells.

Authors:  Jean-Philippe Guégan; Frédéric Ezan; Nathalie Théret; Sophie Langouët; Georges Baffet
Journal:  Carcinogenesis       Date:  2012-10-05       Impact factor: 4.944

8.  Sorafenib for advanced hepatocellular carcinoma (HCC): impact of rationing in the United Kingdom.

Authors:  D H Palmer; S A Hussain; A J Smith; S Hargreaves; Y T Ma; D Hull; P J Johnson; P J Ross
Journal:  Br J Cancer       Date:  2013-07-23       Impact factor: 7.640

9.  Reversing multidrug resistance in hepatocellular carcinoma cells by inhibiting extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activity.

Authors:  Siyuan Chen; Yali Wang; Wenwen Ruan; Xiaomin Wang; Chao Pan
Journal:  Oncol Lett       Date:  2014-09-10       Impact factor: 2.967

10.  BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.

Authors:  Scott M Wilhelm; Christopher Carter; Liya Tang; Dean Wilkie; Angela McNabola; Hong Rong; Charles Chen; Xiaomei Zhang; Patrick Vincent; Mark McHugh; Yichen Cao; Jaleel Shujath; Susan Gawlak; Deepa Eveleigh; Bruce Rowley; Li Liu; Lila Adnane; Mark Lynch; Daniel Auclair; Ian Taylor; Rich Gedrich; Andrei Voznesensky; Bernd Riedl; Leonard E Post; Gideon Bollag; Pamela A Trail
Journal:  Cancer Res       Date:  2004-10-01       Impact factor: 13.312
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  7 in total

Review 1.  The role of mitogen-activated protein kinase-extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation.

Authors:  Samira Kahnamouyi; Mohammad Nouri; Laya Farzadi; Masoud Darabi; Vahid Hosseini; Amir Mehdizadeh
Journal:  Ther Adv Endocrinol Metab       Date:  2018-05-07       Impact factor: 3.565

2.  Interleukin-10 negatively modulates extracellular signal-regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion.

Authors:  Alecsander F Bressan; Gisele A Fonseca; Rita C Tostes; R Clinton Webb; Victor Vitorino Lima; Fernanda Regina Giachini
Journal:  Fundam Clin Pharmacol       Date:  2018-09-07       Impact factor: 2.748

3.  Benzo(a)pyrene promotes Hep-G2 cell migration and invasion by upregulating phosphorylated extracellular signal-regulated kinase expression.

Authors:  Yadong Wang; Teng Pan; Li Li; Haiyu Wang; Ding Zhang; Haiyan Yang
Journal:  Oncol Lett       Date:  2018-03-29       Impact factor: 2.967

4.  p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells.

Authors:  Kanika Sharma; Thien-Trang Vu; Wade Cook; Mitra Naseri; Kevin Zhan; Wataru Nakajima; Hisashi Harada
Journal:  Mol Oncol       Date:  2018-04-17       Impact factor: 6.603

5.  Candidate Biomarkers for Oral Squamous Cell Carcinoma: Differential Expression of Oxidative Stress-Related Genes

Authors:  Nayara Fernandes Pedro; Joice Matos Biselli; José Victor Maniglia; Dalísio de Santi-Neto; Érika Cristina Pavarino; Eny Maria Goloni-Bertollo; Patrícia Matos Biselli-Chicote
Journal:  Asian Pac J Cancer Prev       Date:  2018-05-26

6.  The standardized Korean Red Ginseng extract and its ingredient ginsenoside Rg3 inhibit manifestation of breast cancer stem cell-like properties through modulation of self-renewal signaling.

Authors:  Jisun Oh; Hyo-Jin Yoon; Jeong-Hoon Jang; Do-Hee Kim; Young-Joon Surh
Journal:  J Ginseng Res       Date:  2018-05-17       Impact factor: 6.060

Review 7.  Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer.

Authors:  Monserrat Olea-Flores; Miriam Daniela Zuñiga-Eulogio; Miguel Angel Mendoza-Catalán; Hugo Alberto Rodríguez-Ruiz; Eduardo Castañeda-Saucedo; Carlos Ortuño-Pineda; Teresita Padilla-Benavides; Napoleón Navarro-Tito
Journal:  Int J Mol Sci       Date:  2019-06-13       Impact factor: 5.923
  7 in total

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