Naoya Murakami1, Yoshiki Norihisa2, Fumiaki Isohashi3, Keiko Murofushi4, Takuro Ariga5, Tomoyasu Kato6, Koji Inaba7, Hiroyuki Okamoto7, Yoshinori Ito7, Takafumi Toita5, Jun Itami7. 1. Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan. Electronic address: namuraka@ncc.go.jp. 2. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Radiation Therapy, Bell Land General Hospital, Osaka, Japan. 3. Department of Radiation Oncology, Osaka University Hospital, Osaka, Japan. 4. Department of Radiation Oncology, University of Tsukuba, Ibaraki, Japan. 5. Department of Radiology, Graduate School of Medicine, University of Ryukyus, Okinawa, Japan. 6. Department of Gynecological Oncology, National Cancer Center Hospital, Tokyo, Japan. 7. Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.
Abstract
PURPOSE: The aim of this study was to develop an appropriate definition for vaginal cuff and paracolpium clinical target volume (CTV) for postoperative intensity modulated radiation therapy in patients with uterine cervical cancer. METHODS AND MATERIALS: A working subgroup was organized within the Radiation Therapy Study Group of the Japan Clinical Oncology Group to develop a definition for the postoperative vaginal cuff and paracolpium CTV in December 2013. The group consisted of 5 radiation oncologists who specialized in gynecologic oncology and a gynecologic oncologist. A comprehensive literature review that included anatomy, surgery, and imaging fields was performed and was followed by multiple discreet face-to-face discussions and e-mail messages before a final consensus was reached. RESULTS: Definitions for the landmark structures in all directions that demarcate the vaginal cuff and paracolpium CTV were decided by consensus agreement of the working group. A table was created that showed boundary structures of the vaginal cuff and paracolpium CTV in each direction. CONCLUSIONS: A definition of the postoperative cervical cancer vaginal cuff and paracolpium CTV was developed. It is expected that this definition guideline will serve as a template for future radiation therapy clinical trial protocols, especially protocols involving intensity modulated radiation therapy.
PURPOSE: The aim of this study was to develop an appropriate definition for vaginal cuff and paracolpium clinical target volume (CTV) for postoperative intensity modulated radiation therapy in patients with uterine cervical cancer. METHODS AND MATERIALS: A working subgroup was organized within the Radiation Therapy Study Group of the Japan Clinical Oncology Group to develop a definition for the postoperative vaginal cuff and paracolpium CTV in December 2013. The group consisted of 5 radiation oncologists who specialized in gynecologic oncology and a gynecologic oncologist. A comprehensive literature review that included anatomy, surgery, and imaging fields was performed and was followed by multiple discreet face-to-face discussions and e-mail messages before a final consensus was reached. RESULTS: Definitions for the landmark structures in all directions that demarcate the vaginal cuff and paracolpium CTV were decided by consensus agreement of the working group. A table was created that showed boundary structures of the vaginal cuff and paracolpium CTV in each direction. CONCLUSIONS: A definition of the postoperative cervical cancer vaginal cuff and paracolpium CTV was developed. It is expected that this definition guideline will serve as a template for future radiation therapy clinical trial protocols, especially protocols involving intensity modulated radiation therapy.
Authors: Won Kyung Cho; Heejung Kim; Won Park; Sang-Won Kim; Jongwon Kim; Kang Kyu Lee; Jeong Geun Oh; Mee Sun Yoon; Ju-Young Song; Ki Jung Ahn; Sung Kwang Park; Jin Hwa Choi; Jino Bak Journal: J Radiat Res Date: 2021-01-01 Impact factor: 2.724