Literature DB >> 26766587

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

BaoHan T Vo1, Elmar Wolf2, Daisuke Kawauchi1,3, Anneli Gebhardt2, Jerold E Rehg4, David Finkelstein5, Susanne Walz2,6, Brian L Murphy1, Yong Ha Youn7, Young-Goo Han7, Martin Eilers2,6, Martine F Roussel1.   

Abstract

Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26766587      PMCID： PMC4714043          DOI： 10.1016/j.ccell.2015.12.003

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  38 in total

1.  Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development.

Authors:  Marta Florio; Ketty Leto; Luca Muzio; Andrea Tinterri; Aurora Badaloni; Laura Croci; Paola Zordan; Valeria Barili; Ilaria Albieri; François Guillemot; Ferdinando Rossi; G Giacomo Consalez
Journal:  Development       Date:  2012-07       Impact factor: 6.868

2.  FoxG1 promotes the survival of postmitotic neurons.

Authors:  Somasish Ghosh Dastidar; Paul Michael Zagala Landrieu; Santosh R D'Mello
Journal:  J Neurosci       Date:  2011-01-12       Impact factor: 6.167

3.  An animal model of MYC-driven medulloblastoma.

Authors:  Yanxin Pei; Colin E Moore; Jun Wang; Alok K Tewari; Alexey Eroshkin; Yoon-Jae Cho; Hendrik Witt; Andrey Korshunov; Tracy-Ann Read; Julia L Sun; Earlene M Schmitt; C Ryan Miller; Anne F Buckley; Roger E McLendon; Thomas F Westbrook; Paul A Northcott; Michael D Taylor; Stefan M Pfister; Phillip G Febbo; Robert J Wechsler-Reya
Journal:  Cancer Cell       Date:  2012-02-14       Impact factor: 31.743

4.  A mouse model of the most aggressive subgroup of human medulloblastoma.

Authors:  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; Paul Gibson; Jerold Rehg; Cuilan Gao; David Finkelstein; Chunxu Qu; Stanley Pounds; David W Ellison; Richard J Gilbertson; Martine F Roussel
Journal:  Cancer Cell       Date:  2012-02-14       Impact factor: 31.743

5.  Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.

Authors:  Christian Kosan; Ingrid Saba; Maren Godmann; Stefanie Herold; Barbara Herkert; Martin Eilers; Tarik Möröy
Journal:  Immunity       Date:  2010-12-14       Impact factor: 31.745

Review 6.  MYC on the path to cancer.

Authors:  Chi V Dang
Journal:  Cell       Date:  2012-03-30       Impact factor: 41.582

7.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:  Paul A Northcott; David J H Shih; John Peacock; Livia Garzia; A Sorana Morrissy; Thomas Zichner; Adrian M Stütz; Andrey Korshunov; Jüri Reimand; Steven E Schumacher; Rameen Beroukhim; David W Ellison; Christian R Marshall; Anath C Lionel; Stephen Mack; Adrian Dubuc; Yuan Yao; Vijay Ramaswamy; Betty Luu; Adi Rolider; Florence M G Cavalli; Xin Wang; Marc Remke; Xiaochong Wu; Readman Y B Chiu; Andy Chu; Eric Chuah; Richard D Corbett; Gemma R Hoad; Shaun D Jackman; Yisu Li; Allan Lo; Karen L Mungall; Ka Ming Nip; Jenny Q Qian; Anthony G J Raymond; Nina T Thiessen; Richard J Varhol; Inanc Birol; Richard A Moore; Andrew J Mungall; Robert Holt; Daisuke Kawauchi; Martine F Roussel; Marcel Kool; David T W Jones; Hendrick Witt; Africa Fernandez-L; Anna M Kenney; Robert J Wechsler-Reya; Peter Dirks; Tzvi Aviv; Wieslawa A Grajkowska; Marta Perek-Polnik; Christine C Haberler; Olivier Delattre; Stéphanie S Reynaud; François F Doz; Sarah S Pernet-Fattet; Byung-Kyu Cho; Seung-Ki Kim; Kyu-Chang Wang; Wolfram Scheurlen; Charles G Eberhart; Michelle Fèvre-Montange; Anne Jouvet; Ian F Pollack; Xing Fan; Karin M Muraszko; G Yancey Gillespie; Concezio Di Rocco; Luca Massimi; Erna M C Michiels; Nanne K Kloosterhof; Pim J French; Johan M Kros; James M Olson; Richard G Ellenbogen; Karel Zitterbart; Leos Kren; Reid C Thompson; Michael K Cooper; Boleslaw Lach; Roger E McLendon; Darell D Bigner; Adam Fontebasso; Steffen Albrecht; Nada Jabado; Janet C Lindsey; Simon Bailey; Nalin Gupta; William A Weiss; László Bognár; Almos Klekner; Timothy E Van Meter; Toshihiro Kumabe; Teiji Tominaga; Samer K Elbabaa; Jeffrey R Leonard; Joshua B Rubin; Linda M Liau; Erwin G Van Meir; Maryam Fouladi; Hideo Nakamura; Giuseppe Cinalli; Miklós Garami; Peter Hauser; Ali G Saad; Achille Iolascon; Shin Jung; Carlos G Carlotti; Rajeev Vibhakar; Young Shin Ra; Shenandoah Robinson; Massimo Zollo; Claudia C Faria; Jennifer A Chan; Michael L Levy; Poul H B Sorensen; Matthew Meyerson; Scott L Pomeroy; Yoon-Jae Cho; Gary D Bader; Uri Tabori; Cynthia E Hawkins; Eric Bouffet; Stephen W Scherer; James T Rutka; David Malkin; Steven C Clifford; Steven J M Jones; Jan O Korbel; Stefan M Pfister; Marco A Marra; Michael D Taylor
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

8.  Novel mutations target distinct subgroups of medulloblastoma.

Authors:  Giles Robinson; Matthew Parker; Tanya A Kranenburg; Charles Lu; Xiang Chen; Li Ding; Timothy N Phoenix; Erin Hedlund; Lei Wei; Xiaoyan Zhu; Nader Chalhoub; Suzanne J Baker; Robert Huether; Richard Kriwacki; Natasha Curley; Radhika Thiruvenkatam; Jianmin Wang; Gang Wu; Michael Rusch; Xin Hong; Jared Becksfort; Pankaj Gupta; Jing Ma; John Easton; Bhavin Vadodaria; Arzu Onar-Thomas; Tong Lin; Shaoyi Li; Stanley Pounds; Steven Paugh; David Zhao; Daisuke Kawauchi; Martine F Roussel; David Finkelstein; David W Ellison; Ching C Lau; Eric Bouffet; Tim Hassall; Sridharan Gururangan; Richard Cohn; Robert S Fulton; Lucinda L Fulton; David J Dooling; Kerri Ochoa; Amar Gajjar; Elaine R Mardis; Richard K Wilson; James R Downing; Jinghui Zhang; Richard J Gilbertson
Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

9.  Molecular subgroups of medulloblastoma: the current consensus.

Authors:  Michael D Taylor; Paul A Northcott; Andrey Korshunov; Marc Remke; Yoon-Jae Cho; Steven C Clifford; Charles G Eberhart; D Williams Parsons; Stefan Rutkowski; Amar Gajjar; David W Ellison; Peter Lichter; Richard J Gilbertson; Scott L Pomeroy; Marcel Kool; Stefan M Pfister
Journal:  Acta Neuropathol       Date:  2011-12-02       Impact factor: 17.088

10.  Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.

Authors:  Jiuyi Lu; Minyong Chen; Xiu-Rong Ren; Jiangbo Wang; H Kim Lyerly; Larry Barak; Wei Chen
Journal:  PLoS One       Date:  2013-05-03       Impact factor: 3.240
View more
  32 in total

Review 1.  Family matters: How MYC family oncogenes impact small cell lung cancer.

Authors:  Johannes Brägelmann; Stefanie Böhm; Matthew R Guthrie; Gurkan Mollaoglu; Trudy G Oliver; Martin L Sos
Journal:  Cell Cycle       Date:  2017-07-24       Impact factor: 4.534

Review 2.  Target gene-independent functions of MYC oncoproteins.

Authors:  Apoorva Baluapuri; Elmar Wolf; Martin Eilers
Journal:  Nat Rev Mol Cell Biol       Date:  2020-02-18       Impact factor: 94.444

3.  Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.

Authors:  Steffi Herold; Jacqueline Kalb; Gabriele Büchel; Carsten P Ade; Apoorva Baluapuri; Jiajia Xu; Jan Koster; Daniel Solvie; Anne Carstensen; Christina Klotz; Sabrina Rodewald; Christina Schülein-Völk; Matthias Dobbelstein; Elmar Wolf; Jan Molenaar; Rogier Versteeg; Susanne Walz; Martin Eilers
Journal:  Nature       Date:  2019-03-20       Impact factor: 49.962

4.  Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Authors:  Franz X Schaub; Varsha Dhankani; Ashton C Berger; Mihir Trivedi; Anne B Richardson; Reid Shaw; Wei Zhao; Xiaoyang Zhang; Andrea Ventura; Yuexin Liu; Donald E Ayer; Peter J Hurlin; Andrew D Cherniack; Robert N Eisenman; Brady Bernard; Carla Grandori
Journal:  Cell Syst       Date:  2018-03-28       Impact factor: 10.304

5.  The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain.

Authors:  Xiaoying Chen; Ayan Chanda; Yoshiho Ikeuchi; Xiaoqing Zhang; Jared V Goodman; Naveen C Reddy; Shahriyar P Majidi; Dennis Y Wu; Sarah E Smith; Abigail Godec; Anna Oldenborg; Harrison W Gabel; Guoyan Zhao; Shirin Bonni; Azad Bonni
Journal:  J Neurosci       Date:  2018-11-13       Impact factor: 6.167

6.  The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7.

Authors:  Marion Morel; Krushangi N Shah; Weiwen Long
Journal:  J Biol Chem       Date:  2020-04-28       Impact factor: 5.157

Review 7.  Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment.

Authors:  Juwina Wijaya; Tomoka Gose; John D Schuetz
Journal:  Pharmacol Rev       Date:  2020-07       Impact factor: 25.468

Review 8.  The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.

Authors:  Jerry Vriend; Hassan Marzban
Journal:  Cell Mol Life Sci       Date:  2016-09-03       Impact factor: 9.261

9.  MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.

Authors:  Abbie S Ireland; Alexi M Micinski; David W Kastner; Bingqian Guo; Sarah J Wait; Kyle B Spainhower; Christopher C Conley; Opal S Chen; Matthew R Guthrie; Danny Soltero; Yi Qiao; Xiaomeng Huang; Szabolcs Tarapcsák; Siddhartha Devarakonda; Milind D Chalishazar; Jason Gertz; Justin C Moser; Gabor Marth; Sonam Puri; Benjamin L Witt; Benjamin T Spike; Trudy G Oliver
Journal:  Cancer Cell       Date:  2020-05-30       Impact factor: 31.743

10.  Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.

Authors:  BaoHan T Vo; Chunliang Li; Marc A Morgan; Ilan Theurillat; David Finkelstein; Shaela Wright; Judith Hyle; Stephanie M C Smith; Yiping Fan; Yong-Dong Wang; Gang Wu; Brent A Orr; Paul A Northcott; Ali Shilatifard; Charles J Sherr; Martine F Roussel
Journal:  Cell Rep       Date:  2017-03-21       Impact factor: 9.423
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.