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Literature DB >> 26766581

Polyoxometalate-Driven Self-Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity.

Jingfang Li¹, Zhijun Chen¹, Mengcheng Zhou¹, Jiangbo Jing¹, Wen Li², Yang Wang¹, Lixin Wu¹, Liyan Wang¹, Yanqiu Wang¹, Myongsoo Lee¹.

Abstract

Multivalent peptide nanofibers have attracted intense attention as promising platforms, but the fabrication of those nanofibers is mainly dependent on the spontaneous assembly of β-sheet peptides. Herein we report an alternative approach to the creation of nanofibers: the polyoxometalate-driven self-assembly of short peptides. The resultant nanofibers with concentrated positive charges are excellent multivalent ligands for binding with bacterial cells and thus lead to a salient improvement in bioactivity.

Entities: Chemical

Keywords: bioactivity; ionic self-assembly; multivalent nanofibers; polyoxometalates; short peptides

Mesh：

Substances：

Year: 2016 PMID： 26766581 DOI： 10.1002/anie.201511276

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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