Literature DB >> 26766437

Cybernetics, Redux: An Outside-In Strategy for Unraveling Cellular Function.

Mohan Malleshaiah1, Jeremy Gunawardena2.   

Abstract

A new paper in Science reveals how repetitive stimulation can identify and help to repair fragilities within a signaling network, while using linear mathematical models inspired by engineering, thereby suggesting how cybernetic methods can be integrated into systems and synthetic biology.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26766437     DOI： 10.1016/j.devcel.2015.12.025

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  2 in total

1.  Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling.

Authors:  Javier Estrada; Natalie Andrew; Daniel Gibson; Frederick Chang; Florian Gnad; Jeremy Gunawardena
Journal:  PLoS Comput Biol       Date:  2016-07-01       Impact factor: 4.475

2.  Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies.

Authors:  Pascal Schulthess; Rob C van Wijk; Elke H J Krekels; James W T Yates; Herman P Spaink; Piet H van der Graaf
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2018-04-25
  2 in total

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