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Literature DB >> 26764154

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier.

Abstract

A well-powered clinical trial that failed to replicate promising results in animal models of fragile X syndrome yields important lessons for clinical trial design (Berry-Kravis et al., this issue).

Entities: Disease

Mesh：

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Year: 2016 PMID： 26764154 DOI： 10.1126/scitranslmed.aad9874

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

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Cited

24 in total

1. Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies.

Authors: Max E Joffe; Samuel W Centanni; Anel A Jaramillo; Danny G Winder; P Jeffrey Conn
Journal: ACS Chem Neurosci Date: 2018-06-08 Impact factor: 4.418

2. Developmental timing and critical windows for the treatment of psychiatric disorders.

Authors: Oscar Marín
Journal: Nat Med Date: 2016-10-26 Impact factor: 53.440

Review 3. Advancing the understanding of autism disease mechanisms through genetics.

Authors: Luis de la Torre-Ubieta; Hyejung Won; Jason L Stein; Daniel H Geschwind
Journal: Nat Med Date: 2016-04 Impact factor: 53.440

4. A Psychometric Evaluation of the Motor-Behavioral Assessment Scale for Use as an Outcome Measure in Rett Syndrome Clinical Trials.

Authors: Melissa Raspa; Carla M Bann; Angela Gwaltney; Timothy A Benke; Cary Fu; Daniel G Glaze; Richard Haas; Peter Heydemann; Mary Jones; Walter E Kaufmann; David Lieberman; Eric Marsh; Sarika Peters; Robin Ryther; Shannon Standridge; Steven A Skinner; Alan K Percy; Jeffrey L Neul
Journal: Am J Intellect Dev Disabil Date: 2020-11-01

Clinical trials for neurodevelopmental disorders: At a therapeutic frontier.

1. Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies.

2. Developmental timing and critical windows for the treatment of psychiatric disorders.

Review 3. Advancing the understanding of autism disease mechanisms through genetics.

4. A Psychometric Evaluation of the Motor-Behavioral Assessment Scale for Use as an Outcome Measure in Rett Syndrome Clinical Trials.

Review 5. Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability.

Review 6. Lessons learned from studying syndromic autism spectrum disorders.

7. Schizophrenia genetics complements its mechanistic understanding.

Review 8. Updated report on tools to measure outcomes of clinical trials in fragile X syndrome.

Review 9. The road to precision psychiatry: translating genetics into disease mechanisms.

10. Evaluating atypical language in autism using automated language measures.