Masayuki Sho1, Yoshiaki Murakami2, Manabu Kawai3, Fuyuhiko Motoi4, Sohei Satoi5, Ippei Matsumoto6, Goro Honda7, Kenichiro Uemura2, Hiroaki Yanagimoto5, Masanao Kurata7, Takahiro Akahori1, Shoichi Kinoshita1, Minako Nagai1, Satoshi Nishiwada1, Takumi Fukumoto8, Michiaki Unno4, Hiroki Yamaue3, Yoshiyuki Nakajima1. 1. Department of Surgery, Nara Medical University, Nara, Japan. 2. Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. 3. Second Department of Surgery, Wakayama Medical University, Wakayama, Japan. 4. Division of Gastroenterological Surgery, Department of Surgery, Tohoku University, Sendai, Japan. 5. Department of Surgery, Kansai Medical University, Osaka, Japan. 6. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kinki University Faculty of Medicine, Osaka, Japan. 7. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. 8. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Abstract
BACKGROUND: The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older. METHODS: A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥ 80 years (n = 99) were compared with a control group <80 years of age (n = 1302). RESULTS: There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long-term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy. CONCLUSION: This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
BACKGROUND: The optimal therapeutic strategy for very elderly pancreatic cancerpatients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older. METHODS: A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥ 80 years (n = 99) were compared with a control group <80 years of age (n = 1302). RESULTS: There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long-term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy. CONCLUSION: This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
Authors: Rebecca S Meltzer; David A Kooby; Jeffrey M Switchenko; Jashodeep Datta; Darren R Carpizo; Shishir K Maithel; Mihir M Shah Journal: Ann Surg Oncol Date: 2020-11-03 Impact factor: 5.344
Authors: Danilo Hackner; Mirianna Hobbs; Susanne Merkel; Timo Siepmann; Christian Krautz; Georg F Weber; Robert Grützmann; Maximilian Brunner Journal: Cancers (Basel) Date: 2022-08-15 Impact factor: 6.575