Literature DB >> 26762634

The exocyst in Candida albicans polarized secretion and filamentation.

Alba A Chavez-Dozal1,2, Stella M Bernardo3,4, Samuel A Lee3,4.   

Abstract

The exocyst is an octameric complex that orchestrates the docking and tethering of vesicles to the plasma membrane during exocytosis and is fundamental for key biological processes including growth and establishment of cell polarity. Although components of the exocyst are well conserved among fungi, the specific functions of each component of the exocyst complex unique to Candida albicans biology and pathogenesis are not fully understood. This commentary describes recent findings regarding the role of exocyst subunits Sec6 and Sec15 in C. albicans filamentation and virulence.

Entities:  

Keywords:  Exocyst; Filamentation; Polarisome; SEC15; SEC6; Secretion; Spitzenkörper

Year:  2016        PMID： 26762634      PMCID： PMC4978426          DOI： 10.1007/s00294-015-0553-3

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  20 in total

Review 1.  The exocyst complex in polarized exocytosis.

Authors:  Shu-Chan Hsu; Daniel TerBush; Mathew Abraham; Wei Guo
Journal:  Int Rev Cytol       Date:  2004

2.  Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution.

Authors:  R B Sutton; D Fasshauer; R Jahn; A T Brunger
Journal:  Nature       Date:  1998-09-24       Impact factor: 49.962

3.  Spitzenkorper, exocyst, and polarisome components in Candida albicans hyphae show different patterns of localization and have distinct dynamic properties.

Authors:  Laura A Jones; Peter E Sudbery
Journal:  Eukaryot Cell       Date:  2010-08-06

4.  The secretory pathway: exploring yeast diversity.

Authors:  Marizela Delic; Minoska Valli; Alexandra B Graf; Martin Pfeffer; Diethard Mattanovich; Brigitte Gasser
Journal:  FEMS Microbiol Rev       Date:  2013-04-12       Impact factor: 16.408

5.  Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

Authors:  M Whiteway; D Dignard; D Y Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

6.  Secretion and filamentation are mediated by the Candida albicans t-SNAREs Sso2p and Sec9p.

Authors:  Stella M Bernardo; Hallie S Rane; Alba Chavez-Dozal; Samuel A Lee
Journal:  FEMS Yeast Res       Date:  2014-06-09       Impact factor: 2.796

7.  Functional Analysis of the Exocyst Subunit Sec15 in Candida albicans.

Authors:  Alba A Chavez-Dozal; Stella M Bernardo; Hallie S Rane; Samuel A Lee
Journal:  Eukaryot Cell       Date:  2015-10-09

8.  Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation.

Authors:  Chang-Run Li; Raymond Teck-Ho Lee; Yan-Ming Wang; Xin-De Zheng; Yue Wang
Journal:  J Cell Sci       Date:  2007-05-15       Impact factor: 5.285

9.  The Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and Is a Determinant of Hyphal Branching.

Authors:  Alba A Chavez-Dozal; Stella M Bernardo; Hallie S Rane; Gloria Herrera; Vibhati Kulkarny; Jeanette Wagener; Iain Cunningham; Alexandra C Brand; Neil A R Gow; Samuel A Lee
Journal:  Eukaryot Cell       Date:  2015-05-22

10.  The role of Sec3p in secretory vesicle targeting and exocyst complex assembly.

Authors:  Guangzuo Luo; Jian Zhang; Wei Guo
Journal:  Mol Biol Cell       Date:  2014-09-17       Impact factor: 4.138
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